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https://hdl.handle.net/1822/29562
Título: | Seroprevalence of human papillomavirus 6, 11, 16, and 18 in young primiparous women in Sao Paulo, Brazil |
Autor(es): | Rama, Cristina Helena Villa, Luisa Lina Paglius, Sonia Andreoli, Maria Antonieta Costa, Maria Cecilia Thomann, Patricia Alves, Venâncio Avancini Ferreira Longatto Filho, Adhemar Eluf Neto, José |
Palavras-chave: | HPV serology VLP antibodies Cervical cancer HPV immunization Sexually transmitted disease |
Data: | Nov-2010 |
Editora: | International Gynecologic Cancer Society (IGCS) European Society of Gynaecological Oncology (ESGO) |
Revista: | International Journal of Gynecological Cancer |
Resumo(s): | INTRODUCTION: Data on epidemiology of HPV infection are needed for the development of human papillomavirus (HPV) vaccine recommendations, especially in countries where HPV vaccination is not yet included in public vaccination programs. The aim of this study was to determine the prevalence of serum antibodies to HPV types 6, 11, 16, and 18 and associated factors among young women after birth of the first child. METHODS: This cross-sectional study was carried out in a large public maternity hospital in Sao Paulo, Brazil. Three hundred one women aged 15 to 24 years who gave birth to their first child were recruited between 43 and 60 days after delivery. Seroprevalence was performed using a type-specific enzyme-linked immunosorbent assay based on HPV Late protein 1 viruslike particles. The association of seroreactivity with these 4 HPV types with selected demographic and behavioral factors was assessed by Generalized Linear Model analysis. RESULTS: Fifty-eight (19.3%) women (95% confidence interval, 15.0%-24.2%) had antibodies to any of the 4 viruslike particles tested. The overall seroprevalence rates of the HPV types were: HPV16, 9.0%; HPV18, 7.0%; and HPV 6+11, 7.7%, which are targeted by the HPV prophylactic vaccines. In the multivariate analysis, only age (inversely, P = 0.044 for trend) and previous sexually transmitted disease (P = 0.008) were 2 factors independently associated with HPV seropositivity. CONCLUSIONS: These data offer additional information on the epidemiology of HPV in a group of young Brazilian women after first delivery and contribute to establish a baseline of HPV seroprevalence against which post-HPV vaccine era seroprevalence can be compared. PMID: 21051985 [PubMed - indexed for MEDLINE] |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/29562 |
DOI: | 10.1111/IGC.0b013e3181f3c85e |
ISSN: | 1048-891X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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rama ch_ int gynecol cancer 2010 prep.pdf | 160,2 kB | Adobe PDF | Ver/Abrir |