Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/26978
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Campo DC | Valor | Idioma |
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dc.contributor.author | Novais, Ashley Cruz | - |
dc.contributor.author | Ferreira, Ana C. | - |
dc.contributor.author | Marques, Fernanda | - |
dc.contributor.author | Pêgo, José M. | - |
dc.contributor.author | Cerqueira, João | - |
dc.contributor.author | Pereira, Ana Carla David | - |
dc.contributor.author | Campos, Filipa L. | - |
dc.contributor.author | Dalla, Christina | - |
dc.contributor.author | Kokras, N. | - |
dc.contributor.author | Sousa, Nuno | - |
dc.contributor.author | Palha, Joana Almeida | - |
dc.contributor.author | Sousa, João Carlos | - |
dc.date.accessioned | 2013-12-13T10:55:39Z | - |
dc.date.available | 2013-12-13T10:55:39Z | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 1662-5153 | por |
dc.identifier.uri | https://hdl.handle.net/1822/26978 | - |
dc.description.abstract | Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/dark box (LDB) and novelty suppressed feeding (NSF) tests, but not in the acoustic startle (AS) test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST) of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry. | por |
dc.description.sponsorship | This work is supported by a grant from FCT (PTDC/SAU-OSM/104475/2008) under POCTI-COMPETE funds. Ashley Novais, Ana Catarina Ferreira, Ana David-Pereira and Filipa L. Campos are recipients of doctoral fellowships and Fernanda Marques is a recipient of postdoctoral fellowship from Fundacao para a Ciencia e Tecnologia (FCT), Portugal. We acknowledge Merck Serono for providing the neudesin-null mouse strain. We are thankful to Despina Papasava and Vasileios Kafetzopoulos for the assistance given in the HPLC analysis of neurotransmitters. | por |
dc.language.iso | eng | por |
dc.publisher | Frontiers Media | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/104475/PT | - |
dc.rights | openAccess | por |
dc.subject | Neudesin | por |
dc.subject | Anxiety | por |
dc.subject | Dopamine | por |
dc.subject | Ventral hippocampus | por |
dc.subject | Bed nucleus of the stria terminalis | por |
dc.title | Neudesin is involved in anxiety behavior: structural and neurochemical correlates | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.frontiersin.org/ | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 9 | por |
oaire.citationIssue | 119 | por |
oaire.citationTitle | Frontiers in behavioral neuroscience | por |
oaire.citationVolume | 7 | por |
dc.date.updated | 2013-11-04T13:26:49Z | - |
dc.identifier.doi | 10.3389/fnbeh.2013.00119 | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Frontiers in behavioral neuroscience | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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novais a_front behav neurosc 2013.pdf | 1,46 MB | Adobe PDF | Ver/Abrir |