Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/25221

TitleSelf-collection for high-risk HPV detection in Brazilian women using the care HPV™ test
Author(s)Lorenzi, Adriana Tarlá
Fregnani, José Humberto
Possati-Resende, Júlio César
Neto, Cristovam Scapulatempo
Villa, Luisa Lina
Longatto Filho, Adhemar
KeywordsHuman papillomavirus
Cervical cancer
Self-sampling
Molecular test
Screening
Issue date2013
PublisherElsevier
JournalGynecologic Oncology
Abstract(s)Cervical cancer is the second most common cancer among Brazilian women. High-risk human papillomavirus (hr-HPV) persistence is the primary cause of cervical neoplasia. Early detection of hr-HPV is important for identifying women at risk for developing cervical lesions. Approximately 85% of new cases of cervical cancer worldwide and 50% of the total cervical cancer deaths occurred in developing countries. Here, a new methodology to support a cervical cancer screening program was evaluated in women from various Brazilian regions. METHODS: Two thousand women aged 18-77years were enrolled in an opportunistic cervical cancer screening program and were randomized into self-vaginal or health professional-guided cervical sampling groups. The Qiagen careHPV™ test was performed on all samples. Pap tests were performed on all women using liquid-based cytology. RESULTS: Positive hr-HPV results were obtained in 12.3% (245/2000) of women; similar rates were observed in self- or health professional-collected samples. Eighty-nine percent (1719/2000) of cervical cytologies classified as normal were negative to hr-HPV. Among the cytological samples, 36.6% classified as ASC-US+ were positive to hr-HPV, 78.8% were LSIL and 75.0% were HSIL. CONCLUSIONS: Self-sampled and health professional-sampled vaginal/cervical specimens did not differ in their rates of detection of hr-HPV. Therefore, HPV DNA testing in self-sampled vaginal cells is an alternative to primary screening in low-resource settings.
TypeArticle
URIhttp://hdl.handle.net/1822/25221
DOI10.1016/j.ygyno.2013.07.092
ISSN0090-8258
Publisher versionwww.journals.elsevier.com/gynecologic-oncology/?
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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