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https://hdl.handle.net/1822/25192| Título: | TLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survival |
| Autor(es): | Menino, João Filipe Saraiva, Margarida Alves, Ana G. Gomes Lobo-Silva, Diogo Sturme, Mark H. J. Gomes, Jéssica Angélica Rezende Saraiva, Ana Laura Goldman, Gustavo H. Cunha, Cristina Carvalho, Agostinho Romani, Luigina Pedrosa, Jorge Castro, António Gil Rodrigues, Fernando |
| Data: | Jul-2013 |
| Editora: | Public Library of Science (PLOS) |
| Revista: | PLoS Neglected Tropical Diseases |
| Resumo(s): | Background: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both TLR2 and TLR4 have been implicated in the recognition of P. brasiliensis and regulation of the immune response. However, the role of TLR9 during the infection by this fungus remains unclear. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/25192 |
| DOI: | 10.1371/journal.pntd.0002317 |
| ISSN: | 1935-2735 |
| Versão da editora: | http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002317 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| menino j_plosnegltropdis 2013.pdf | 5,23 MB | Adobe PDF | Ver/Abrir |
