Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/25192

TitleTLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survival
Author(s)Menino, João Filipe
Saraiva, Margarida
Alves, Ana G. Gomes
Lobo-Silva, Diogo
Sturme, Mark H. J.
Gomes, Jéssica Angélica Rezende
Saraiva, Ana Laura
Goldman, Gustavo H.
Cunha, Cristina
Carvalho, Agostinho
Romani, Luigina
Pedrosa, Jorge
Castro, António Gil
Rodrigues, Fernando
Issue dateJul-2013
PublisherPublic Library of Science (PLOS)
JournalPLoS Neglected Tropical Diseases
Abstract(s)Background: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both TLR2 and TLR4 have been implicated in the recognition of P. brasiliensis and regulation of the immune response. However, the role of TLR9 during the infection by this fungus remains unclear.
TypeArticle
URIhttp://hdl.handle.net/1822/25192
DOI10.1371/journal.pntd.0002317
ISSN1935-2735
Publisher versionhttp://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002317
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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