Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/25189
Título: | Frequency of TERT promoter mutations in human cancers |
Autor(es): | Vinagre, João Almeida, Ana Pópulo, Helena Batista, Rui Lyra, Joana Pinto, Vasco Coelho, Ricardo Celestino, Ricardo Prazeres, Hugo Lima, Luís Melo, Miguel Rocha, Adriana Gaspar da Preto, Ana Castro, Patrícia Castro, Ligia Pardal, Fernando Lopes, José Manuel Santos Lúcio, Lara Reis, R. M. Cameselle-Teijeiro, José Sobrinho-Simões, Manuel Lima, Jorge Máximo, Valdemar Soares, Paula |
Data: | 9-Jul-2013 |
Editora: | Palgrave Macmillan |
Revista: | Nature communications |
Resumo(s): | Reactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring together with BRAF mutations) is significantly associated with higher TERT mRNA expression, and in glioblastoma we find a trend for increased telomerase expression in cases harbouring TERT promoter mutations. Both in thyroid cancers and glioblastoma, TERT promoter mutations are significantly associated with older age of the patients. Our results show that TERT promoter mutations are relatively frequent in specific types of human cancers, where they lead to enhanced expression of telomerase. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/25189 |
DOI: | 10.1038/ncomms3185 |
ISSN: | 2041-1723 |
Versão da editora: | http://www.nature.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
vinagre j_nat commun 2013 posp.pdf | 415,3 kB | Adobe PDF | Ver/Abrir |