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https://hdl.handle.net/1822/25090
Título: | Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits |
Autor(es): | Carvalho, Miguel Campos, Filipa L. Coimbra, Bárbara Guimarães Salazar Pêgo, José M. Lima, Rui Rodrigues, Ana João Sousa, Nuno Salgado, A. J. |
Palavras-chave: | Parkinson’s disease 6-OHDA Motor behavior Emotion Levodopa Bupropion Paroxetine |
Data: | 22-Abr-2013 |
Editora: | BioMed Central (BMC) |
Revista: | Molecular Neurodegeneration |
Resumo(s): | BACKGROUND: Parkinson's disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have focused on the emergence of non-motor symptoms in PD patients, as a consequence of damage on the mesolimbic and mesocortical dopaminergic networks, and on their significant impact on the quality of life of PD patients. Herein, we performed a thorough behavioral analysis including motor, emotional and cognitive dimensions, of the unilateral medial forebrain bundle (MFB) 6-hydroxidopamine (6-OHDA)-lesioned model of PD, and further addressed the impact of pharmacological interventions with levodopa and antidepressants on mood dimensions. RESULTS: Based on apomorphine-induced turning behaviour and degree of dopaminergic degeneration, animals submitted to MFB lesions were subdivided in complete and incomplete lesion groups. Importantly, this division also translated into a different severity of motor and exploratory impairments and depressive-like symptoms; in contrast, no deficits in anxiety-like and cognitive behaviors were found in MFB-lesioned animals. Subsequently, we found that the exploratory and the anhedonic behavioural alterations of MFB-lesioned rats can be partially improved with the administration of both levodopa or the antidepressant bupropion, but not paroxetine. CONCLUSIONS: Our results suggest that this model is a relevant tool to study the pathophysiology of motor and non-motor symptoms of PD. In addition, the present data shows that pharmacological interventions modulating dopaminergic transmission are also relevant to revert the non-motor behavioral deficits found in the disease. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/25090 |
DOI: | 10.1186/1750-1326-8-14 |
ISSN: | 1750-1326 |
Versão da editora: | http://www.biomedcentral.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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mm carvalho_molecular degenration_2013.pdf | 761,7 kB | Adobe PDF | Ver/Abrir |