Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/24881

TitleChitosan/bioactive glass nanoparticle composite membranes for periodontal regeneration
Author(s)Mota, Joana
Yu, Na
Caridade, S. G.
Luz, Gisela
Gomes, Manuela E.
Reis, R. L.
Jansen, John A.
Walboomers, X. Frank
Mano, J. F.
KeywordsBiomaterials
Tissue engineering
Guided tissue regeneration
Chitosan
Nanoparticles
Issue date2012
PublisherElsevier
JournalActa Biomaterialia
Abstract(s)Barrier membranes are used in periodontal applications with the aim of supporting periodontal regeneration by physically blocking migration of epithelial cells. The present work proposes a combination of chitosan (CHT) with bioactive glass nanoparticles (BG-NPs) in order to produce a novel guided tissue and bone regeneration membrane, fabricated by solvent casting. The CHT/BG-NP nanocomposite membranes are characterized in terms of water uptake, in mechanical tests, under simulated physiological conditions and in in vitro bioactivity tests. The addition of BG-NPs to CHT membranes decreased the mechanical potential of these membranes, but on the other hand the bioactivity improved. The membranes containing the BG-NPs induced the precipitation of bone-like apatite in simulated body fluid (SBF). Biological tests were carried out using human periodontal ligament cells and human bone marrow stromal cells. CHT/BG-NP composite membranes promoted cell metabolic activity and mineralization. The results indicate that the CHT/BG-NP composite membrane could potentially be used as a temporary guided tissue regeneration membrane in periodontal regeneration, with the possibility to induce bone regeneration.
TypeArticle
URIhttp://hdl.handle.net/1822/24881
DOI10.1016/j.actbio.2012.06.040
ISSN1742-7061
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S1742706112002978
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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