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https://hdl.handle.net/1822/24881
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Campo DC | Valor | Idioma |
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dc.contributor.author | Mota, Joana | - |
dc.contributor.author | Yu, Na | - |
dc.contributor.author | Caridade, S. G. | - |
dc.contributor.author | Luz, Gisela | - |
dc.contributor.author | Gomes, Manuela E. | - |
dc.contributor.author | Reis, R. L. | - |
dc.contributor.author | Jansen, John A. | - |
dc.contributor.author | Walboomers, X. Frank | - |
dc.contributor.author | Mano, J. F. | - |
dc.date.accessioned | 2013-07-30T11:47:49Z | - |
dc.date.available | 2013-07-30T11:47:49Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1742-7061 | por |
dc.identifier.uri | https://hdl.handle.net/1822/24881 | - |
dc.description.abstract | Barrier membranes are used in periodontal applications with the aim of supporting periodontal regeneration by physically blocking migration of epithelial cells. The present work proposes a combination of chitosan (CHT) with bioactive glass nanoparticles (BG-NPs) in order to produce a novel guided tissue and bone regeneration membrane, fabricated by solvent casting. The CHT/BG-NP nanocomposite membranes are characterized in terms of water uptake, in mechanical tests, under simulated physiological conditions and in in vitro bioactivity tests. The addition of BG-NPs to CHT membranes decreased the mechanical potential of these membranes, but on the other hand the bioactivity improved. The membranes containing the BG-NPs induced the precipitation of bone-like apatite in simulated body fluid (SBF). Biological tests were carried out using human periodontal ligament cells and human bone marrow stromal cells. CHT/BG-NP composite membranes promoted cell metabolic activity and mineralization. The results indicate that the CHT/BG-NP composite membrane could potentially be used as a temporary guided tissue regeneration membrane in periodontal regeneration, with the possibility to induce bone regeneration. | por |
dc.description.sponsorship | This work was financially supported by the Foundation for Science and Technology (FCT) within the project PTDC/CTM-BPC/112774/2009. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.rights | openAccess | por |
dc.subject | Biomaterials | por |
dc.subject | Tissue engineering | por |
dc.subject | Guided tissue regeneration | por |
dc.subject | Chitosan | por |
dc.subject | Nanoparticles | por |
dc.title | Chitosan/bioactive glass nanoparticle composite membranes for periodontal regeneration | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S1742706112002978 | por |
dc.comments | http://www.3bs.uminho.pt/node/15887 | - |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 4173 | por |
oaire.citationEndPage | 4180 | por |
oaire.citationIssue | 11 | por |
oaire.citationTitle | Acta Biomaterialia | por |
oaire.citationVolume | 8 | por |
dc.date.updated | 2013-07-30T10:05:22Z | - |
dc.identifier.doi | 10.1016/j.actbio.2012.06.040 | por |
dc.identifier.pmid | 22771458 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Acta Biomaterialia | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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15887-Mota J et al.pdf | 1,23 MB | Adobe PDF | Ver/Abrir |