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TitleIn vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein
Author(s)Martins, Margarida Isabel Barros Coelho
Azóia, Nuno G.
Ribeiro, Artur J.
Shimanovich, Ulyana
Silva, Carla Manuela Pereira Marinho da
Paulo, Artur Cavaco
Transdermal perfusion
Hydrophilic macromolecules
Issue date2013
PublisherElsevier Science BV
JournalColloids and Surfaces B: Biointerfaces
Abstract(s)Transdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66 kDa) of 160 nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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