In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein

doi:10.1016/j.colsurfb.2013.02.032

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/24342

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Campo DC	Valor	Idioma
dc.contributor.author	Martins, Margarida Isabel Barros Coelho	-
dc.contributor.author	Azóia, Nuno G.	-
dc.contributor.author	Ribeiro, Artur J.	-
dc.contributor.author	Shimanovich, Ulyana	-
dc.contributor.author	Silva, Carla Manuela Pereira Marinho da	-
dc.contributor.author	Paulo, Artur Cavaco	-
dc.date.accessioned	2013-06-05T17:15:15Z	-
dc.date.available	2013-06-05T17:15:15Z	-
dc.date.issued	2013	-
dc.identifier.issn	0927-7765	por
dc.identifier.uri	https://hdl.handle.net/1822/24342	-
dc.description.abstract	Transdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66 kDa) of 160 nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications.	por
dc.description.sponsorship	We thank Matadouro - Central Carnes de Entre Douro e Minho, Lda for their support on pig samples. The histological studies were supported by the Department of Histology from Life and Health Sciences Research Institute (ICVS), University of Minho. The confocal 3D images were performed by Department of Chemistry and Kanbar Laboratory for Nanomaterials Bar-Ilan University Center for Advanced Materials and Nanotechnology. Carla Silva would like to thanks Fundacao para a Ciencia e a Tecnologia for their funding (SFRH/BPD/46515/2008).	por
dc.language.iso	eng	por
dc.publisher	Elsevier Science BV	por
dc.rights	openAccess	por
dc.subject	Protein	por
dc.subject	Surfactant	por
dc.subject	Nanodispersion	por
dc.subject	Transdermal perfusion	por
dc.subject	Hydrophilic macromolecules	por
dc.title	In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein	por
dc.type	article	por
dc.peerreviewed	yes	por
dc.relation.publisherversion	http://ac.els-cdn.com/S0927776513001616/1-s2.0-S0927776513001616-main.pdf?_tid=b4f90438-ce03-11e2-b26a-00000aacb35e&acdnat=1370452789_82fbaa692916dc26190e9496b22234ca	por
sdum.publicationstatus	published	por
oaire.citationStartPage	271	por
oaire.citationEndPage	278	por
oaire.citationTitle	Colloids and Surfaces B: Biointerfaces	por
oaire.citationVolume	108	por
dc.publisher.uri	Elsevier BV	por
dc.identifier.doi	10.1016/j.colsurfb.2013.02.032	por
dc.identifier.pmid	23563294	por
dc.subject.wos	Science & Technology	por
sdum.journal	Colloids and Surfaces B: Biointerfaces	por
Aparece nas coleções:	CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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