Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/24145
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Campo DC | Valor | Idioma |
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dc.contributor.author | Syrjänen, K. | - |
dc.contributor.author | Shabalova, I. | - |
dc.contributor.author | Sarian, L. | - |
dc.contributor.author | Naud, P. | - |
dc.contributor.author | Filho, A. L. | - |
dc.contributor.author | Derchain, S. | - |
dc.contributor.author | Kozachenko, V | - |
dc.contributor.author | Zakharchenko, S. | - |
dc.contributor.author | Martins, C. Roteli | - |
dc.contributor.author | Nerovjna, R. | - |
dc.contributor.author | Kljukina, L. | - |
dc.contributor.author | Tatti, S. | - |
dc.contributor.author | Branovskaja, M. | - |
dc.contributor.author | Branca, M. | - |
dc.contributor.author | Grunjberga, V. | - |
dc.contributor.author | Eržen, M. | - |
dc.contributor.author | Juschenko, A. | - |
dc.contributor.author | Hammes, L. Serpa | - |
dc.contributor.author | Podistov, J. | - |
dc.contributor.author | Costa, S. | - |
dc.contributor.author | Syrjänen, S. | - |
dc.date.accessioned | 2013-05-21T17:52:12Z | - |
dc.date.available | 2013-05-21T17:52:12Z | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 0392-2936 | por |
dc.identifier.uri | https://hdl.handle.net/1822/24145 | - |
dc.description | Special thanks are due to Digene Corp. for providing the Hybrid Capture analyzer, samplers and the test kits at our disposal. We express our thanks to all women who participated in these two cohort studies. Finally, all the members of the NIS and LAMS Study research groups are acknowledged for their invaluable contribution to these studies | por |
dc.description.abstract | The complex natural history of human papillomavirus (HPV) infections following a single HPV test can be modeled as competing-risks events (i.e., no-, transient- or persistent infection) in a longitudinal setting. The covariates associated with these competing events have not been previously assessed using competing-risks regression models. OBJECTIVES: To gain further insights in the outcomes of cervical HPV infections, we used univariate- and multivariate competing-risks regression models to assess the covariates associated with these competing events. STUDY DESIGN AND METHODS: Covariates associated with three competing outcomes (no-, transient- or persistent HR-HPV infection) were analysed in a sub-cohort of 1,865 women prospectively followed-up in the NIS (n = 3,187) and LAMS Study (n = 12,114). RESULTS: In multivariate competing-risks models (with two other outcomes as competing events), permanently HR-HPV negative outcome was significantly predicted only by the clearance ofASCUS+ Pap during FU, while three independent covariates predicted transient HR-HPV infections: i) number of recent (< 12 months) sexual partners (risk increased), ii) previous Pap screening history (protective), and history of previous CIN (increased risk). The two most powerful predictors of persistent HR-HPV infections were persistent ASCUS+ Pap (risk increased), and previous Pap screening history (protective). In pair-wise comparisons, number of recent sexual partners and previous CIN history increase the probability of transient HR-HPV infection against the HR-HPV negative competing event, while previous Pap screening history is protective. Persistent ASCUS+ Pap during FU and no previous Pap screening history are significantly associated with the persistent HR-HPV outcome (compared both with i) always negative, and ii) transient events), whereas multiparity is protective. CONCLUSIONS: Different covariates are associated with the three main outcomes of cervical HPV infections. The most significant covariates of each competing events are probably distinct enough to enable constructing of a risk-profile for each main outcome. | por |
dc.description.sponsorship | The NIS Cohort study has been supported by the INCO-Copernicus Program of the European Commission (Contract No. ERB IC15-CT98-0321), and the LAMS study by the European Commission, INCO-DEV Programme (Contract# ICA4-CT-2001-10013). | por |
dc.language.iso | eng | por |
dc.publisher | I.R.O.G. Canada Inc. | por |
dc.rights | restrictedAccess | por |
dc.subject | HPV | por |
dc.subject | Natural history | por |
dc.subject | Outcomes | por |
dc.subject | Competing events | por |
dc.subject | Competing-risks regression model | por |
dc.subject | Transient infection | por |
dc.subject | Persistent infection | por |
dc.subject | Prospective follow-up | por |
dc.subject | NIS Cohort | por |
dc.subject | LAMS Study | por |
dc.title | Longitudinal outcomes of high-risk human papillomavirus (HPV) infections as competing-risks events following cervical HPV test at baseline visit in the *NIS-LAMS** cohort | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.irog.net/en-CA/index.aspx?CatID=2 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 341 | por |
oaire.citationEndPage | 352 | por |
oaire.citationIssue | 4 | por |
oaire.citationTitle | European Journal of Gynaecological Oncology | por |
oaire.citationVolume | 33 | por |
dc.identifier.pmid | 23091888 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | European Journal of Gynaecological Oncology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Syrjänen K_Eur. J. Gynaec. Oncol 2012b.pdf Acesso restrito! | Documento principal | 103,01 kB | Adobe PDF | Ver/Abrir |