Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/24093

TitleDectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis
Author(s)Carvalho, Agostinho
Giovannini, Gloria
De Luca, Antonella
D’Angelo, Carmen
Casagrande, Andrea
Iannitti, Rossana G.
Ricci, Giovanni
Cunha, Cristina
Romani, Luigina
KeywordsDectin-1
Mucosal candidiasis
Th1/Th17
II-22
genetic background
Mucosal candidiasis, Th1/Th17, Il-22, genetic background
Issue dateMay-2012
PublisherNature Publishing Group
JournalCellular and Molecular Immunology
Abstract(s)Recognition of β-glucans by dectin-1 has been shown to mediate cell activation, cytokine production and a variety of antifungal responses. Here, we report that the functional activity of dectin-1 in mucosal immunity to Candida albicans is influenced by the genetic background of the host. Dectin-1 was required for the proper control of gastrointestinal and vaginal candidiasis in C57BL/6 but not BALB/c mice, the latter actually showing increased resistance in the absence of dectin-1. Susceptibility of dectin-1-deficient C57BL/6 mice to infection was associated with defective IL-17A, aryl hydrocarbon receptor-dependent IL-22 production as well as adaptive Th1 responses. In contrast, resistance of dectin-1-deficient BALB/c mice was associated with increased IL-17A and IL-22 production, and the skewing towards Th1/Treg immune responses that provide immunological memory. Disparate canonical/noncanonical NF-κB signaling pathways downstream dectin-1were activated in the two different mouse strains. Thus, the net activity of dectin-1 in antifungal mucosal immunity is dependent on the host’s genetic background that affects both the innate cytokine production as well as the adaptive Th1/Th17 cell activation upon dectin-1 signaling.
TypeArticle
DescriptionWe thank Dr. Cristina Massi Benedetti for digital art and editing
URIhttp://hdl.handle.net/1822/24093
DOI10.1038/cmi.2012.1
ISSN1672-7681
Publisher versionhttp://dx.doi.org/10.1038/cmi.2012.1
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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