Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/23918

TitleDAMP signaling in fungal infections and diseases
Author(s)Cunha, Cristina
Carvalho, Agostinho
Esposito, Antonella
Bistoni, Francesco
Romani, Luigina
KeywordsDAMPs
PAMPs
Fungal diseases
Inflammation
Immunoregulation
Issue dateSep-2012
PublisherFrontiers Media
JournalFrontiers in Immunology
Abstract(s)Fungal infections and diseases predominantly affect patients with deregulated immunity. Compelling experimental and clinical evidence indicate that severe fungal diseases belong to the spectrum of fungus-related inflammatory diseases. Some degree of inflammation is required for protection during the transitional response occurring temporally between the rapid innate and slower adaptive response. However, progressive inflammation worsens disease and ultimately prevents pathogen eradication. The challenge now is to elucidate cellular and molecular pathways distinguishing protective vs. pathogenic inflammation to fungi. In addition to fungal ligands of pattern recognition receptors (pathogen-associated molecular patterns, PAMPs), several host-encoded proteins, the damage-associated molecular patterns (DAMPs), are released during tissue injury and activate innate recognition receptors. DAMPs have been shown to regulate inflammation in fungal diseases. The DAMP/receptor for advanced glycation end-products axis integrated with the PAMP/Toll-like receptors axis in the generation of the inflammatory response in experimental and clinical fungal pneumonia. These emerging themes better accommodate fungal pathogenesis in the face of high-level inflammation seen in several clinical settings and point to DAMP targeting as a novel immunomodulatory strategy in fungal diseases.
TypeArticle
URIhttp://hdl.handle.net/1822/23918
DOI10.3389/fimmu.2012.00286
ISSN1664-3224
Publisher versionhttp://dx.doi.org/10.3389%2Ffimmu.2012.00286
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
Cunha Cristina_Front Immunol. 2012.pdfDocumento principal1,01 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID