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https://hdl.handle.net/1822/23780
Título: | Implementing human papillomavirus testing in a public health hospital : challenges and opportunities |
Autor(es): | Beldi, Mariana Carmezim Tacla, Maricy Caiaffa-Filho, Helio Ab’Saber, Alexandre Siqueira, Sheila Baracat, Edmund Chada Alves, Venâncio Avancini Ferreira Longatto Filho, Adhemar |
Palavras-chave: | Cytology Pap test Human papillomavirus testing Primary screening |
Data: | 2012 |
Editora: | Karger AG |
Revista: | Acta Cytologica |
Resumo(s): | OBJECTIVES: Robust evidence now supports human papillomavirus (HPV) testing as a more effective option to screening and as more sensitive than cytology in detecting high-grade cervical intraepithelial neoplasia . Our goal was to analyze the performance of the Hybrid Capture II (HC2) assay for high-risk HPV (hrHPV) in women undergoing gynecological examination at a public health hospital as part of the evaluation of HPV screening as an alternative or complement to cytology. STUDY DESIGN: This analysis is a subset of a cross-sectional study carried out at a large public hospital serving a predominantly low-resource population. A total of 705 women were enrolled; the sensitivity and specificity of each test were estimated and compared. RESULTS: The analysis identified 272 hrHPV-positive women (mean age 36.3 years) and 433 hrHPV-negative women (mean age 41.2 years). HPV testing showed a significantly increased sensitivity of the HC2 assay versus cytology (84.5 vs. 69.7%; p < 0.0001) but a lower specificity (49.90 vs. 88.78%; p < 0.0001). CONCLUSION: The combination of both methods seems to be useful in improving detection of cervical lesions. |
Tipo: | Artigo |
Descrição: | Author's proof. The authors are indebted to Luciane Sarahyba and Nazareno dos Santos of the Molecular Biology Laboratory for their technical assistance. |
URI: | https://hdl.handle.net/1822/23780 |
DOI: | 10.1159/000335145 |
ISSN: | 0001-5547 |
Versão da editora: | www.karger.com/acy |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Beldi M_Acta Cytologica 2012 pp.pdf | Author's proof | 216,24 kB | Adobe PDF | Ver/Abrir |