Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/23649
Título: | Bioactive macro/micro porous silk fibroin/Nano-sized calcium phosphate scaffolds with potential for bone tissue engineering applications |
Autor(es): | Yan, Leping Silva-Correia, Joana Correia, C. Caridade, S. G. Fernandes, E. M. Sousa, R. A. Mano, J. F. Oliveira, Joaquim M. Oliveira, A. L. Reis, R. L. |
Palavras-chave: | Bone tissue engineering Calcium phosphate Nanocomposite Scaffold Silk fibroin nano-sized calcium phosphate porous scaffold |
Data: | 2013 |
Editora: | Future Medicine |
Revista: | Nanomedicine |
Resumo(s): | Aim: The development of novel silk/nano-sized calcium phosphate (silk/nano-CaP) scaffolds with highly dispersed CaP nanoparticles in the silk fibroin (SF) matrix for bone tissue engineering. Materials & methods: Nano-CaP was incorporated in a concentrated aqueous SF solution (16 wt.%) by using an in situ synthesis method. The silk/nano-CaP scaffolds were then prepared through a combination of salt-leaching/ lyophilization approaches. Results: The CaP particles presented good affinity to SF and their size was inferior to 200 nm when theoretical CaP/silk ratios were between 4 and 16 wt.%, as determined by scanning electron microscopy. The CaP particles displayed a uniform distribution in the scaffolds at both microscopic and macroscopic scales as observed by backscattered scanning electron microscopy and micro-computed tomography, respectively. The prepared scaffolds presented self-mineralization capability and no cytotoxicity confirmed by in vitro bioactivity tests and cell viability assays, respectively. Conclusion: These results indicated that the produced silk/nano-CaP scaffolds could be suitable candidates for bone-tissueengineering applications. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/23649 |
DOI: | 10.2217/NNM.12.118 |
ISSN: | 1743-5889 |
Versão da editora: | http://www.futuremedicine.com/doi/abs/10.2217/nnm.12118?journalCode=nnm |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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15838-SCaP.pdf | 1,47 MB | Adobe PDF | Ver/Abrir |