Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/23649

TítuloBioactive macro/micro porous silk fibroin/Nano-sized calcium phosphate scaffolds with potential for bone tissue engineering applications
Autor(es)Yan, Leping
Correia, Joana Silva
Correia, C.
Caridade, S. G.
Fernandes, E. M.
Sousa, R. A.
Mano, J. F.
Oliveira, Joaquim M.
Oliveira, A. L.
Reis, R. L.
Palavras-chaveBone tissue engineering
Calcium phosphate
Nanocomposite
Scaffold
Silk fibroin
Data2013
EditoraFuture Medicine
RevistaNanomedicine
Resumo(s)Aim: The development of novel silk/nano-sized calcium phosphate (silk/nano-CaP) scaffolds with highly dispersed CaP nanoparticles in the silk fibroin (SF) matrix for bone tissue engineering. Materials & methods: Nano-CaP was incorporated in a concentrated aqueous SF solution (16 wt.%) by using an in situ synthesis method. The silk/nano-CaP scaffolds were then prepared through a combination of salt-leaching/ lyophilization approaches. Results: The CaP particles presented good affinity to SF and their size was inferior to 200 nm when theoretical CaP/silk ratios were between 4 and 16 wt.%, as determined by scanning electron microscopy. The CaP particles displayed a uniform distribution in the scaffolds at both microscopic and macroscopic scales as observed by backscattered scanning electron microscopy and micro-computed tomography, respectively. The prepared scaffolds presented self-mineralization capability and no cytotoxicity confirmed by in vitro bioactivity tests and cell viability assays, respectively. Conclusion: These results indicated that the produced silk/nano-CaP scaffolds could be suitable candidates for bone-tissueengineering applications.
Tipoarticle
URIhttp://hdl.handle.net/1822/23649
ISSN1743-5889
Versão da editorahttp://www.futuremedicine.com/doi/abs/10.2217/nnm.12118?journalCode=nnm
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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