Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/23649

Full metadata record
DC FieldValueLanguage
dc.contributor.authorYan, Leping-
dc.contributor.authorSilva-Correia, Joana-
dc.contributor.authorCorreia, C.-
dc.contributor.authorCaridade, S. G.-
dc.contributor.authorFernandes, E. M.-
dc.contributor.authorSousa, R. A.-
dc.contributor.authorMano, J. F.-
dc.contributor.authorOliveira, Joaquim M.-
dc.contributor.authorOliveira, A. L.-
dc.contributor.authorReis, R. L.-
dc.date.accessioned2013-04-10T14:06:26Z-
dc.date.available2013-04-10T14:06:26Z-
dc.date.issued2013-
dc.date.submitted2012-07-
dc.identifier.issn1743-5889por
dc.identifier.urihttp://hdl.handle.net/1822/23649-
dc.description.abstractAim: The development of novel silk/nano-sized calcium phosphate (silk/nano-CaP) scaffolds with highly dispersed CaP nanoparticles in the silk fibroin (SF) matrix for bone tissue engineering. Materials & methods: Nano-CaP was incorporated in a concentrated aqueous SF solution (16 wt.%) by using an in situ synthesis method. The silk/nano-CaP scaffolds were then prepared through a combination of salt-leaching/ lyophilization approaches. Results: The CaP particles presented good affinity to SF and their size was inferior to 200 nm when theoretical CaP/silk ratios were between 4 and 16 wt.%, as determined by scanning electron microscopy. The CaP particles displayed a uniform distribution in the scaffolds at both microscopic and macroscopic scales as observed by backscattered scanning electron microscopy and micro-computed tomography, respectively. The prepared scaffolds presented self-mineralization capability and no cytotoxicity confirmed by in vitro bioactivity tests and cell viability assays, respectively. Conclusion: These results indicated that the produced silk/nano-CaP scaffolds could be suitable candidates for bone-tissueengineering applications.por
dc.description.sponsorshipThis study was funded by the Portuguese Foundation for Science and Technology (FCT) through the projects Tissue2Tissue (PTDC/CTM/105703/2008) and Osteo Cart (PTDC/CTM-BPC/115977/2009). The funding from Foundation Luso-Americana is greatly acknowledged. L-P Yan gives thanks for his PhD scholarship from FCT (SFRHIBD/64717/2009). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or potions, expert testimony, grants or patents received or pending, or royalties.por
dc.language.isoengpor
dc.publisherFuture Medicinepor
dc.rightsopenAccesspor
dc.subjectBone tissue engineeringpor
dc.subjectCalcium phosphatepor
dc.subjectNanocompositepor
dc.subjectScaffoldpor
dc.subjectSilk fibroinpor
dc.subjectnano-sized calcium phosphatepor
dc.subjectporous scaffoldpor
dc.titleBioactive macro/micro porous silk fibroin/Nano-sized calcium phosphate scaffolds with potential for bone tissue engineering applicationspor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.futuremedicine.com/doi/abs/10.2217/nnm.12118?journalCode=nnmpor
dc.commentshttp://www.3bs.uminho.pt/node/15838por
sdum.publicationstatuspublishedpor
oaire.citationStartPage359por
oaire.citationEndPage378por
oaire.citationIssue3por
oaire.citationTitleNanomedicinepor
oaire.citationVolume8por
dc.date.updated2013-04-08T13:29:13Z-
dc.identifier.doi10.2217/NNM.12.118por
dc.subject.wosScience & Technologypor
sdum.journalNanomedicinepor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
15838-SCaP.pdf1,47 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID