Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/21073

TítuloDo genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia
Autor(es)Palha, Joana Almeida
Santos, Nadine Correia
Marques, Fernanda Cristina Gomes de Sousa
Sousa, João
Bessa, João
Miguelote, Rui
Sousa, Nuno
Belmonte-de-Abreu, Paulo
Palavras-chaveNeurodevelopment
Choroid plexus
Schizophrenia
Cerebrospinal fluid
Brain ventricles
Ventriculomegaly
DataAgo-2012
EditoraFrontiers Media
RevistaFrontiers in Cllular Neuroscience
Resumo(s)Schizophrenia is a neurodevelopment disorder in which the interplay of genes and environment contributes to disease onset and establishment. The most consistent pathological feature in schizophrenic patients is an enlargement of the brain ventricles. Yet, so far, no study has related this finding with dysfunction of the choroid plexus (CP), the epithelial cell monolayer located within the brain ventricles that is responsible for the production of most of the cerebrospinal fluid (CSF). Enlarged brain ventricles are already present at the time of disease onset (young adulthood) and, of notice, isolated mild ventriculomegaly detected in utero is associated with subsequent mild neurodevelopmental abnormalities similar to those observed in children at high risk of developing schizophrenia. Here we propose that altered CP/CSF dynamics during neurodevelopment may be considered a risk, causative and/or participating factor for development of schizophrenia.
Tipoarticle
URIhttp://hdl.handle.net/1822/21073
DOI10.3389/fncel.2012.00031
ISSN1662-5102
Versão da editorahttp://www.frontiersin.org/Cellular_Neuroscience/10.3389/fncel.2012.00031/abstract
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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