Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/21073

TítuloDo genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia
Autor(es)Palha, Joana Almeida
Santos, Nadine Correia
Marques, Fernanda Cristina Gomes de Sousa
Sousa, João
Bessa, João
Miguelote, Rui
Sousa, Nuno
Belmonte-de-Abreu, Paulo
Choroid plexus
Cerebrospinal fluid
Brain ventricles
EditoraFrontiers Media
RevistaFrontiers in Cllular Neuroscience
Resumo(s)Schizophrenia is a neurodevelopment disorder in which the interplay of genes and environment contributes to disease onset and establishment. The most consistent pathological feature in schizophrenic patients is an enlargement of the brain ventricles. Yet, so far, no study has related this finding with dysfunction of the choroid plexus (CP), the epithelial cell monolayer located within the brain ventricles that is responsible for the production of most of the cerebrospinal fluid (CSF). Enlarged brain ventricles are already present at the time of disease onset (young adulthood) and, of notice, isolated mild ventriculomegaly detected in utero is associated with subsequent mild neurodevelopmental abnormalities similar to those observed in children at high risk of developing schizophrenia. Here we propose that altered CP/CSF dynamics during neurodevelopment may be considered a risk, causative and/or participating factor for development of schizophrenia.
Versão da editorahttp://www.frontiersin.org/Cellular_Neuroscience/10.3389/fncel.2012.00031/abstract
Arbitragem científicayes
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Palha JA_Front Cell Neurosc 2012.pdfDocumento principal544,96 kBAdobe PDFVer/Abrir

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu Currículo DeGóis