Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/19081
Título: | Glucocorticoid regulation of astrocytic fate and function |
Autor(es): | Yu, Shuang Yang, Silei Holsboer, F. Sousa, Nuno Almeida, O. F. X. |
Data: | 2011 |
Editora: | Public Library of Science |
Revista: | PLoS ONE |
Resumo(s): | Glial loss in the hippocampus has been suggested as a factor in the pathogenesis of stress-related brain disorders that are characterized by dysregulated glucocorticoid (GC) secretion. However, little is known about the regulation of astrocytic fate by GC. Here, we show that astrocytes derived from the rat hippocampus undergo growth inhibition and display moderate activation of caspase 3 after exposure to GC. Importantly, the latter event, observed both in situ and in primary astrocytic cultures is not followed by either early- or late-stage apoptosis, as monitored by stage I or stage II DNA fragmentation. Thus, unlike hippocampal granule neurons, astrocytes are resistant to GC-induced apoptosis; this resistance is due to lower production of reactive oxygen species (ROS) and a greater buffering capacity against the cytotoxic actions of ROS. We also show that GC influence hippocampal cell fate by inducing the expression of astrocyte-derived growth factors implicated in the control of neural precursor cell proliferation. Together, our results suggest that GC instigate a hitherto unknown dialog between astrocytes and neural progenitors, adding a new facet to understanding how GC influence the cytoarchitecture of the hippocampus. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/19081 |
DOI: | 10.1371/journal.pone.0022419 |
ISSN: | 1932-6203 |
Versão da editora: | http://www.plosone.org |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Yu S_PlosOne 2011.pdf | Documento principal | 1,21 MB | Adobe PDF | Ver/Abrir |