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https://hdl.handle.net/1822/19011
Título: | Mycobacteria-induced anaemia revisited : a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin |
Autor(es): | Rodrigues, Pedro Gomes, Sandro S. Neves, João V. Pereira, Sandra Gomes Neves, Margarida Correia Alves, Cláudio Nunes Stolte, Jens Sanchez, Mayka Appelberg, Rui Muckenthaler, Martina U. Gomes, M. Salomé |
Palavras-chave: | Mycobacteria Anaemia Ipocalin-2 NRAMP1 Hepcidin Lipocalin-2 |
Data: | Out-2011 |
Editora: | Elsevier 1 |
Revista: | Immunobiology |
Resumo(s): | Anaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron metabolism induced by infection. We show that four weeks after infection with Mycobacterium avium BALB/c mice exhibited a moderate anaemia, which was not accompanied by an increase on hepatic hepcidin mRNA expression. Instead, infected mice presented increased mRNA expression of ferroportin (Slc40a1), ceruloplasmin (Cp), hemopexin (Hpx), heme-oxygenase-1 (Hmox1) and lipocalin-2 (Lcn2). Both the anaemia and the mRNA expression changes of iron-related genes were largely absent in C.D2 mice which bear a functional allele of the Nramp1 gene. Data presented in this work suggest that anaemia due to a chronic mycobacterial infection may develop in the absence of elevated hepcidin expression, is influenced by Nramp1 and may involve lipocalin-2. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/19011 |
DOI: | 10.1016/j.imbio.2011.04.004 |
ISSN: | 0171-2985 |
Versão da editora: | http://www.sciencedirect.com/science/article/pii/S0171298511000751 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Rodrigues P_Immunobiology-prep 2011.pdf | Versão preprint | 4,64 MB | Adobe PDF | Ver/Abrir |