Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/18684

Full metadata record
DC FieldValueLanguage
dc.contributor.authorMartins, Sandra-
dc.contributor.authorReis, R. M.-
dc.contributor.authorRodrigues, António Mesquita-
dc.contributor.authorBaltazar, Fátima-
dc.contributor.authorLongatto Filho, Adhemar-
dc.date.accessioned2012-04-17T13:52:03Z-
dc.date.available2012-04-17T13:52:03Z-
dc.date.issued2011-06-
dc.identifier.issn2218-4333por
dc.identifier.urihttp://hdl.handle.net/1822/18684-
dc.description.abstractColorectal cancer (CRC) is one of the cancer models and most of the carcinogenic steps are presently well understood. Therefore, successful preventive measures are currently used in medical practice. However, CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide. Nowadays, pathologic stage is a unique and well-recognized prognostic indica¬tor, however, more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment. Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial. Probably the most important clinical implication of tumor angiogen¬esis is the development of anti-angiogenic therapy. The goal of this review is to critically evaluate the role of angiogenic markers, assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in anti-angiogenic therapies.por
dc.language.isoengpor
dc.publisherBaishideng Publishing Grouppor
dc.rightsopenAccesspor
dc.subjectAngiogenesispor
dc.subjectColorectal cancerpor
dc.subjectColorectal cancer treatmentpor
dc.subjectEndoglinpor
dc.subjectPrognosispor
dc.subjectVascular endo¬thelial growth factorpor
dc.titleRole of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapiespor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.wjgnet.com/2218-4333/full/v2/i6/272.htmpor
oaire.citationStartPage272por
oaire.citationEndPage280por
oaire.citationIssue6por
oaire.citationTitleWorld Journal of Clinical Oncologypor
oaire.citationVolume2por
dc.identifier.doi10.5306/wjco.v2.i6.272por
dc.subject.wosScience & Technologypor
sdum.journalWorld Journal of Clinical Oncologypor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
Martins S_WJCO 2011.pdfDocumento principal794,62 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID