Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/91186
Título: | pH-sensitive nanoliposomes for passive and CXCR-4-mediated marine yessotoxin delivery for cancer therapy |
Autor(es): | Vieira, Ana M. G. Silvestre, Oscar F. Silva, Bruno F. B. Ferreira, Celso J. O. Lopes, Ivo Edgar Araújo Gomes, Andreia C Espiña, Begoña Passos, Marisa Sárria Pereira |
Palavras-chave: | Anticancer activity CXCR-4-targeting Dinoflagellates Passive targeting pH-sensitive nanoliposomes Prostate and breast cancer treatment Yessotoxin |
Data: | 2022 |
Editora: | Future Medicine |
Revista: | Nanomedicine |
Citação: | Vieira AM, Silvestre OF, Silva BF, Ferreira CJ, Lopes I, Gomes AC, Espiña B, Sárria MP. pH-sensitive nanoliposomes for passive and CXCR-4-mediated marine yessotoxin delivery for cancer therapy. Nanomedicine (Lond). 2022 Apr;17(10):717-739. doi: 10.2217/nnm-2022-0010. Epub 2022 Apr 28. PMID: 35481356. |
Resumo(s): | Background: Yessotoxin (YTX), a marine-derived drug, was encapsulated in PEGylated pH-sensitive nanoliposomes, covalently functionalized (strategy I) with SDF-1α and by nonspecific adsorption (strategy II), to actively target chemokine receptor CXCR-4. Methods: Cytotoxicity to normal human epithelial cells (HK-2) and prostate (PC-3) and breast (MCF-7) adenocarcinoma models, with different expression levels of CXCR-4, were tested. Results: Strategy II exerted the highest cytotoxicity toward cancer cells while protecting normal epithelia. Acid pH-induced fusion of nanoliposomes seemed to serve as a primary route of entry into MCF-7 cells but PC-3 data support an endocytic pathway for their internalization. Conclusion: This work describes an innovative hallmark in the current marine drug clinical pipeline, as the developed nanoliposomes are promising candidates in the design of groundbreaking marine flora-derived anticancer nanoagents. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/91186 |
DOI: | 10.2217/nnm-2022-0010 |
ISSN: | 1743-5889 |
Versão da editora: | https://www.futuremedicine.com/doi/10.2217/nnm-2022-0010 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CBMA - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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nnm-2022-0010.pdf Acesso restrito! | 4,48 MB | Adobe PDF | Ver/Abrir |