Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/91186
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Vieira, Ana M. G. | por |
dc.contributor.author | Silvestre, Oscar F. | por |
dc.contributor.author | Silva, Bruno F. B. | por |
dc.contributor.author | Ferreira, Celso J. O. | por |
dc.contributor.author | Lopes, Ivo Edgar Araújo | por |
dc.contributor.author | Gomes, Andreia C | por |
dc.contributor.author | Espiña, Begoña | por |
dc.contributor.author | Passos, Marisa Sárria Pereira | por |
dc.date.accessioned | 2024-04-22T13:01:14Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Vieira AM, Silvestre OF, Silva BF, Ferreira CJ, Lopes I, Gomes AC, Espiña B, Sárria MP. pH-sensitive nanoliposomes for passive and CXCR-4-mediated marine yessotoxin delivery for cancer therapy. Nanomedicine (Lond). 2022 Apr;17(10):717-739. doi: 10.2217/nnm-2022-0010. Epub 2022 Apr 28. PMID: 35481356. | por |
dc.identifier.issn | 1743-5889 | - |
dc.identifier.uri | https://hdl.handle.net/1822/91186 | - |
dc.description.abstract | Background: Yessotoxin (YTX), a marine-derived drug, was encapsulated in PEGylated pH-sensitive nanoliposomes, covalently functionalized (strategy I) with SDF-1α and by nonspecific adsorption (strategy II), to actively target chemokine receptor CXCR-4. Methods: Cytotoxicity to normal human epithelial cells (HK-2) and prostate (PC-3) and breast (MCF-7) adenocarcinoma models, with different expression levels of CXCR-4, were tested. Results: Strategy II exerted the highest cytotoxicity toward cancer cells while protecting normal epithelia. Acid pH-induced fusion of nanoliposomes seemed to serve as a primary route of entry into MCF-7 cells but PC-3 data support an endocytic pathway for their internalization. Conclusion: This work describes an innovative hallmark in the current marine drug clinical pipeline, as the developed nanoliposomes are promising candidates in the design of groundbreaking marine flora-derived anticancer nanoagents. | por |
dc.description.sponsorship | This article received funding from the Nanotechnology-Based Functional Solutions (NORTE-01-0145-FEDER-000019), supported by North Portugal Regional Operational Programme (NORTE2020) under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (ERDF). MP Sárria and OF Silvestre were supported by Marie Skłodowska-Curie Actions from European Union's 7th Framework Programme for Research, Technological Development and Demonstration under Grant Agreement 600375. AC Gomes acknowledges the strategic programme UID/BIA/04050/2020, funded by national funds through Fundação para a Ciência e Tecnologia I.P, and I.L. doctoral grant M3.1.a/F/128/2015 supported by Fundo Regional for Ciência e Tecnologia da Região Autónoma dos Açores. | por |
dc.language.iso | eng | por |
dc.publisher | Future Medicine | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04050%2F2020/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Anticancer activity | por |
dc.subject | CXCR-4-targeting | por |
dc.subject | Dinoflagellates | por |
dc.subject | Passive targeting | por |
dc.subject | pH-sensitive nanoliposomes | por |
dc.subject | Prostate and breast cancer treatment | por |
dc.subject | Yessotoxin | por |
dc.title | pH-sensitive nanoliposomes for passive and CXCR-4-mediated marine yessotoxin delivery for cancer therapy | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.futuremedicine.com/doi/10.2217/nnm-2022-0010 | por |
oaire.citationStartPage | 717 | por |
oaire.citationEndPage | 739 | por |
oaire.citationIssue | 10 | por |
oaire.citationVolume | 17 | por |
dc.identifier.doi | 10.2217/nnm-2022-0010 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 35481356 | por |
dc.subject.fos | Engenharia e Tecnologia::Nanotecnologia | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Nanomedicine | por |
oaire.version | VoR | por |
dc.subject.ods | Saúde de qualidade | por |
Aparece nas coleções: | CBMA - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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nnm-2022-0010.pdf Acesso restrito! | 4,48 MB | Adobe PDF | Ver/Abrir |