Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/90035
Título: | Evaluation of novel dendrimer-gold complex nanoparticles for theranostic application in oncology |
Autor(es): | Milivojevic, Nevena Carvalho, Mariana Rodrigues Caballero, David Radisavljevic, Snezana Radoicic, Marija Živanović, Marko Kundu, Subhas C Reis, R. L. Filipović, Nenad Oliveira, Joaquim M. |
Palavras-chave: | Dendrimers Microfluidics Nanoparticles Au-complex Colorectal cancer Dendrimer nanoparticles Nano-oncology Nanomedicine |
Data: | Jan-2024 |
Editora: | Taylor & Francis |
Revista: | Nanomedicine |
Citação: | Milivojevic N., Carvalho M. R., Caballero D., Radisavljevic S., Radoicic M., Živanović M., Kundu S. C., Reis R. L., Filipović N., Oliveira J. M. Evaluation of novel dendrimer–gold complex nanoparticles for theranostic application in oncology, Nanomedicine, doi:10.2217/nnm-2023-0355, 2023 |
Resumo(s): | Aim: Despite some successful examples of therapeutic nanoparticles reaching clinical stages, there is still a significant need for novel formulations in order to improve the selectivity and efficacy of cancer treatment. Methods: The authors developed two novel dendrimerâ gold (Au) complex-based nanoparticles using twodifferent synthesis routes: complexation method (formulation A) and precipitation method (formulation B). Using a biomimetic cancer-on-a-chip model, the authors evaluated the possible cytotoxicity and internalization by colorectal cancer cells of dendrimerâ Au complex-based nanoparticles. Results: The results showed promising capabilities of these nanoparticles for selectively targeting cancer cells and delivering drugs, particularly for the formulation A nanoparticles. Conclusion: This work highlights the potential of dendrimerâ Au complex-based nanoparticles as a new strategy to improve the targeting of anticancer drugs. |
Tipo: | Artigo |
Descrição: | To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/nnm-2023-0355 |
URI: | https://hdl.handle.net/1822/90035 |
DOI: | 10.2217/nnm-2023-0355 |
ISSN: | 1743-5889 |
e-ISSN: | 1748-6963 |
Versão da editora: | https://www.futuremedicine.com/doi/epub/10.2217/nnm-2023-0355 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
21024-milivojević-et-al-2024-evaluation-novel-dendrimer-gold-complex-nanoparticles-theranostic-applicatio.pdf | 12,03 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons