Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/89994
Título: | Thermosensitive chitosan/poly(N-isopropyl acrylamide) nanoparticles embedded in aniline pentamer/silk fibroin/polyacrylamide as an electroactive injectable hydrogel for healing critical-sized calvarial bone defect in aging rat model |
Autor(es): | Zarrin, Negin Khaneh Mottaghitalab, Fatemeh Reis, R. L. Kundu, Subhas C Farokhi, Mehdi |
Palavras-chave: | Thermosensitive nanoparticles Conductivity Injectable hydrogel Bone regeneration |
Data: | Mai-2022 |
Editora: | Elsevier 1 |
Revista: | International Journal of Biological Macromolecules |
Citação: | Zarrin N. K., Mottaghitalab F., Reis R. L., Kundu S. C., Farokhi M. Thermosensitive chitosan/poly(N-isopropyl acrylamide) nanoparticles embedded in aniline pentamer/silk fibroin/polyacrylamide as an electroactive injectable hydrogel for healing critical-sized calvarial bone defect in aging rat model, International Journal of Biological Macromolecules Volume 213, Vol. 213, pp. 352-368, doi:https://doi.org/10.1016/j.ijbiomac.2022.05.176, 2022 |
Resumo(s): | Thermosensitive nanoparticles with phase transition abilities have been considered as suitable materials in biomedical fields, especially drug delivery systems. Moreover, electroactive injectable hydrogels supporting bone regeneration of the elderly will highly be desired in bone tissue engineering applications. Herein, thermosensitive nanoparticles were fabricated using chitosan/poly(N-isopropyl acrylamide) for simvastatin acid delivery. The nanoparticles were incorporated into electroactive injectable hydrogels based on aniline pentamer/silk fibroin/polyacrylamide containing vitamin C. The nanoparticles had thermosensitive properties as simvastatin acid had higher release rates at 37 than 23 °C without significant burst release. The hydrogels also revealed an appropriate gelation time, stable mechanical and rheological characteristics, high water absorbency, and proper biodegradability. In vitro studies indicated that the hydrogel was biocompatible and nontoxic, especially those containing drugs. Implantation of the hydrogels containing both simvastatin acid and vitamin C into the critical calvarial bone defect of the aged rat also demonstrated significant enhancement of bone healing after 4 and 8 weeks post-implantation. We found that the electroactive injectable hydrogels containing thermosensitive nanoparticles exhibited great potential for treating bone defects in the elderly rats |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/89994 |
DOI: | 10.1016/j.ijbiomac.2022.05.176 |
ISSN: | 0141-8130 |
e-ISSN: | 1879-0003 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0141813022011667?via%3Dihub |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21105-1-s20-s0141813022011667-main.pdf | 7,69 MB | Adobe PDF | Ver/Abrir |