Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/89109
Título: | Macrophage cell membrane infused biomimetic liposomes for glioblastoma targeted therapy |
Autor(es): | Mendanha, D. Vieira de Castro, J. Casanova, Marta Alexandra Rodrigues Gimondi, Sara Ferreira, H. Neves, N. M. |
Palavras-chave: | Biomimetic liposomes Cell membrane Glioblastoma Macrophages |
Data: | Abr-2023 |
Editora: | Elsevier 1 |
Revista: | Nanomedicine: Nanotechnology, Biology, and Medicine |
Citação: | Mendanha D., Vieira de Castro J., Casanova M. R., Gimondi S., Ferreira H., Neves N. M. Macrophage cell membrane infused biomimetic liposomes for glioblastoma targeted therapy, Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 49, pp. 102663, 1549-9642, 2023 |
Resumo(s): | Glioblastoma (GBM) is a highly aggressive malignant brain tumor currently without an effective treatment. Inspired by the recent advances in cell membrane biomimetic nanocarriers and by the key role of macrophages in GBM pathology, we developed macrophage membrane liposomes (MML) for GBM targeting. For the first time, it was assessed the role of macrophage polarization states in the effectiveness of these drug delivery systems. Interestingly, we observed that MML derived from M2 macrophages (M2 MML) presents higher uptake and increased delivery of the anticarcinogenic drug doxorubicin compared to M1 macrophage-derived nanocarriers (M1 MML) and control liposomes (CL). Moreover, the lowest uptake by macrophages of MML reveals promising immune escaping properties. Notably, M2 macrophages unveiled a higher expression of integrin CD49d, a crucial protein involved in the bilateral communication of macrophages with tumor cells. Therefore, our findings suggest the potential of using M2 macrophage membranes to develop novel nanocarriers targeting GBM. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/89109 |
DOI: | 10.1016/j.nano.2023.102663 |
ISSN: | 1549-9634 |
e-ISSN: | 1549-9642 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S154996342300014X?via%3Dihub |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21033-macrophage-cell-membrane-infused-biomimetic-liposomes.pdf Acesso restrito! | 4,64 MB | Adobe PDF | Ver/Abrir |