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https://hdl.handle.net/1822/88754
Título: | Stromal vascular fraction obtained from subcutaneous adipose tissue: ex-obese and older population as main clinical targets |
Autor(es): | Frias, Frias Matos, Beatriz Jarnalo, Mariana Freitas-Ribeiro, Sara Reis, R. L. Pirraco, Rogério P. Horta, Ricardo |
Palavras-chave: | Adipose-derived stem cells CD90 Regenerative medicine Stromal vascular fraction |
Data: | Nov-2022 |
Editora: | Elsevier 1 |
Revista: | Journal of Surgical Research |
Citação: | Frias F., Matos B., Jarnalo M., Freitas-Ribeiro S., Reis R. L., Pirraco R. P., Horta R. Stromal Vascular Fraction Obtained From Subcutaneous Adipose Tissue: Ex-Obese and Older Population as Main Clinical Targets, Journal Of Surgical Research, Vol. 283, pp. 632-639, doi:10.1016/j.jss.2022.11.012, 2022 |
Resumo(s): | Introduction Human adipose tissue contains a heterogeneous and synergistic mixture of cells called stromal vascular fraction (SVF) with highly proliferative and angiogenic properties, conferring promising applicability in the field of regenerative medicine. This study aims to investigate if age, body mass index (BMI), history of obesity and massive weight loss, and harvest site are related to SVF cell marker expression. Methods A total of 26 samples of subcutaneous adipose tissue were harvested from patients admitted to the Plastic and Reconstructive department in University Hospital Center of São João, Porto, Portugal, for body contouring surgery. The percentage of cells expressing CD31, CD34, CD45, CD73, CD90, and CD105 was assessed and compared with patient's age, BMI, history of obesity and massive weight loss (ex-obese group), and harvest site. Results In the ex-obese group, a significantly higher number of cells expressing CD90 (P = 0.002) was found. BMI, harvest site, and age appear to have no association with SVF subpopulations. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/88754 |
DOI: | 10.1016/j.jss.2022.11.012 |
ISSN: | 1095-8673 |
e-ISSN: | 0022-4804 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S002248042200751X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20912-1-s20-s002248042200751x-main.pdf | 619,55 kB | Adobe PDF | Ver/Abrir |