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TitleMonocyte-derived macrophages and dermal fibroblasts-derived ECM making small talk
Author(s)Chaves, S.
Macedo, J.
Reis, Daniel Pedro Pires Alves
Silva, Lucília Pereira
Marques, A. P.
Issue dateJul-2023
PublisherMary Ann Liebert
JournalTissue Engineering. Part A
CitationChaves S., Macedo J., Reis D. P., da Silva L. P., Marques A. P. Monocyte-derived macrophages and dermal fibroblasts-derived ECM making small talk, TISSUE ENGINEERING: Part A, Vol. 29, Issue 13-14, pp. 255, doi:10.1089/ten.tea.2023.29043.abstracts, 2023
Abstract(s)[Excerpt] Introduction: 3D in vitro skin models allow studying molecular pathways that otherwise are only possible to explore using animal models. The incorporation of immune cells, such as macrophages, has been implemented to create immunocompetent analogues. Yet, the human biology representation in those models is limited, among other aspects, by the minimal extracellular matrix (ECM) mimicry[1]. In order to tackle this limitation, we have established a protocol to extract fibroblasts-own ECM. In this work, we hypothesised that those ECM extracts were not able to promote macrophage activation, which could compromise the physiologic phenotype of the model. [...]
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AccessOpen access
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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