Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/86433
Título: | 2-Oxo-2H-benzo[h]benzopyran as a new light sensitive protecting group for neurotransmitter amino acids |
Autor(es): | Soares, Ana M. S. Costa, Susana P. G. Gonçalves, M. Sameiro T. |
Palavras-chave: | Oxobenzobenzopyran Coumarin Neurotransmitters Amino acids Photocleavable protecting groups |
Data: | 2010 |
Editora: | Springer |
Revista: | Amino Acids |
Citação: | Soares, A.M.S., Costa, S.P.G. & Gonçalves, M.S.T. 2-Oxo-2H-benzo[h]benzopyran as a new light sensitive protecting group for neurotransmitter amino acids. Amino Acids 39, 121–133 (2010). https://doi.org/10.1007/s00726-009-0383-z |
Resumo(s): | Aiming at the development of new benzopyran-based photocleavable protecting groups, novel chloromethylated and hydroxymethylated 2-oxo-2H-benzo[h]benzopyran derivatives bearing a methoxy substituent were designed and used in the synthesis of a series of fluorescent bioconjugates, by linking through an ester or urethane bond to several model neurotransmitter amino acids (glycine, alanine, beta-alanine and gamma-aminobutyric acid, GABA). The resulting fluorescent bioconjugates with emission in the visible range and high fluorescent quantum yields, were subjected to photocleavage reaction in methanol/HEPES buffer (80:20) solution at different wavelengths of irradiation (250, 300, 350 and 419 nm) and photocleavage kinetic data were obtained. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/86433 |
DOI: | 10.1007/s00726-009-0383-z |
ISSN: | 0939-4451 |
Versão da editora: | https://link.springer.com/article/10.1007/s00726-009-0383-z#citeas |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Final revised manuscript.pdf Acesso restrito! | Author's Accepted Manuscript | 572,52 kB | Adobe PDF | Ver/Abrir |