Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/86433
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Soares, Ana M. S. | por |
dc.contributor.author | Costa, Susana P. G. | por |
dc.contributor.author | Gonçalves, M. Sameiro T. | por |
dc.date.accessioned | 2023-09-18T13:54:06Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Soares, A.M.S., Costa, S.P.G. & Gonçalves, M.S.T. 2-Oxo-2H-benzo[h]benzopyran as a new light sensitive protecting group for neurotransmitter amino acids. Amino Acids 39, 121–133 (2010). https://doi.org/10.1007/s00726-009-0383-z | por |
dc.identifier.issn | 0939-4451 | por |
dc.identifier.uri | https://hdl.handle.net/1822/86433 | - |
dc.description.abstract | Aiming at the development of new benzopyran-based photocleavable protecting groups, novel chloromethylated and hydroxymethylated 2-oxo-2H-benzo[h]benzopyran derivatives bearing a methoxy substituent were designed and used in the synthesis of a series of fluorescent bioconjugates, by linking through an ester or urethane bond to several model neurotransmitter amino acids (glycine, alanine, beta-alanine and gamma-aminobutyric acid, GABA). The resulting fluorescent bioconjugates with emission in the visible range and high fluorescent quantum yields, were subjected to photocleavage reaction in methanol/HEPES buffer (80:20) solution at different wavelengths of irradiation (250, 300, 350 and 419 nm) and photocleavage kinetic data were obtained. | por |
dc.description.sponsorship | Thanks are due to the Foundation for Science and Technology (Portugal) for financial support through project PTDC/QUI/69607/2006. The NMR spectrometer Bruker Avance III 400 is part of the National NMR Network and was acquired with funds from FCT and FEDER. | por |
dc.language.iso | eng | por |
dc.publisher | Springer | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FQUI%2F69607%2F2006/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Oxobenzobenzopyran | por |
dc.subject | Coumarin | por |
dc.subject | Neurotransmitters | por |
dc.subject | Amino acids | por |
dc.subject | Photocleavable protecting groups | por |
dc.title | 2-Oxo-2H-benzo[h]benzopyran as a new light sensitive protecting group for neurotransmitter amino acids | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s00726-009-0383-z#citeas | por |
oaire.citationStartPage | 121 | por |
oaire.citationEndPage | 133 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 39 | por |
dc.date.updated | 2023-09-03T09:10:59Z | - |
dc.identifier.doi | 10.1007/s00726-009-0383-z | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 19908122 | - |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
dc.subject.wos | Science & Technology | - |
sdum.export.identifier | 12732 | - |
sdum.journal | Amino Acids | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Final revised manuscript.pdf Acesso restrito! | Author's Accepted Manuscript | 572,52 kB | Adobe PDF | Ver/Abrir |