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https://hdl.handle.net/1822/85420
Título: | Electroconductive poly(3,4‑ethylenedioxythiophene) (PEDOT) nanoparticle‑loaded silk fibroin biocomposite conduits for peripheral nerve regeneration |
Autor(es): | Escobar, Ane Serafin, Aleksandra Carvalho, Mariana Rodrigues Culebras, Mario Cantarero, Andres Beaucamp, Anne Reis, R. L. Oliveira, Joaquim M. Collins, Maurice N. |
Palavras-chave: | Conductivity Electroconductive polymers Nanoparticles Nerve guidance conduits Peripheral Nerve Regeneration |
Data: | Mai-2023 |
Editora: | Springer |
Revista: | Advanced Composites and Hybrid Materials |
Citação: | Escobar A., Serafin A., Carvalho M. R., Culebras M., Cantarero A., Beaucamp A., Reis R. L., Oliveira J. M., Collins M. N. Electroconductive poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticle-loaded silk fibroin biocomposite conduits for peripheral nerve regeneration, Advanced Composites and Hybrid Materials , doi:10.1007/s42114-023-00689-2, 2023 |
Resumo(s): | Peripheral nerve injury (PNI) often clinically relies on the use of nerve grafts taken from the patient to establish a therapeutic effect, though secondary site of injury and morbidity have prompted the medical community to find alternative solutions. A new trend in the development of biomaterials arises in the form of electro-conductive biomaterials, especially for electrically active tissues such as the peripheral nerves. In this work, novel poly(3,4-ethylenedioxythiophene) PEDOT nanoparticles (PEDOT NPs) were synthetized via the mini-emulsion method and were combined with silk fibroin (SF) to create conduits for PNI repair. The synthesized PEDOT NPs-loaded SF conduits showed optimal properties for peripheral nerve substitution from the physico-chemical and biological point of view. They displayed excellent mechanical and conductivity performance with the tensile moduli reaching 6.61â ±â 0.55 MPa and the conduits reaching 5.4 · 10â 4 S cmâ 1, respectively. The conduits did not possess apatite-forming capacity, which were resistant to bending occlusions for angles up to 50° and to suturing. The developed conduits are promising as a novel biomaterial for applications in peripheral nerve regeneration; in vitro experiments showed that they did not allow BJ fibroblast infiltration, avoiding scar tissue formation in the lumen, and they did not show any toxic effect for Schwann cells. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/85420 |
DOI: | 10.1007/s42114-023-00689-2 |
ISSN: | 2522-0128 |
e-ISSN: | 2522-0136 |
Versão da editora: | https://link.springer.com/article/10.1007/s42114-023-00689-2 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20945-anne.pdf | 4,25 MB | Adobe PDF | Ver/Abrir |