The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models

doi:10.3390/vetsci9110636

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/81321

Título:	The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models
Autor(es):	Teixeira, Silvia A. Luzzi, Mayara de Cassia Martin, Ana Carolina Baptista Moreno Duarte, Terence Teixeira Leal, Mônica de Oliveira Teixeira, Gustavo Ramos Reis, Monise Tadin Junior, Carlos Roberto Almeida Santos, Karina Melendez, Matias Eliseo Silva, Diego da Cunha Silveira Alves da Bernécule, Priscila Neves Firmino, Higor Vinicius Lourenço Alves, Ana Laura Vieira Guimarães, Denise Peixoto Borduqui, João Vitor Laus, Ana Carolina Mançano, Bruna Minniti Reis, R. M.
Palavras-chave:	PTCH1-knockout Apc<sup>Min</sup> xenografts PDX genetically engineered mouse models personalized therapy tumor biology Apc(Min)
Data:	16-Nov-2022
Editora:	Multidisciplinary Digital Publishing Institute
Revista:	Veterinary Sciences
Citação:	Teixeira, S.A.; Luzzi, M.d.C.; Martin, A.C.B.M.; Duarte, T.T.; Leal, M.d.O.; Teixeira, G.R.; Reis, M.T.; Junior, C.R.A.; Santos, K.; Melendez, M.E.; Silva, D.d.C.S.A.d.; Bernécule, P.N.; Firmino, H.V.L.; Alves, A.L.V.; Guimarães, D.P.; Borduqui, J.V.; Laus, A.C.; Mançano, B.M.; Reis, R.M. The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models. Vet. Sci. 2022, 9, 636. https://doi.org/10.3390/vetsci9110636
Resumo(s):	The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and <i>Apc<sup>Min</sup></i> mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.
Tipo:	Artigo
URI:	https://hdl.handle.net/1822/81321
DOI:	10.3390/vetsci9110636
e-ISSN:	2306-7381
Versão da editora:	https://www.mdpi.com/2306-7381/9/11/636
Arbitragem científica:	yes
Acesso:	Acesso aberto
Aparece nas coleções:	ICVS - Artigos em revistas internacionais / Papers in international journals