The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models

doi:10.3390/vetsci9110636

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/81321

Registo completo

Campo DC	Valor	Idioma
dc.contributor.author	Teixeira, Silvia A.	por
dc.contributor.author	Luzzi, Mayara de Cassia	por
dc.contributor.author	Martin, Ana Carolina Baptista Moreno	por
dc.contributor.author	Duarte, Terence Teixeira	por
dc.contributor.author	Leal, Mônica de Oliveira	por
dc.contributor.author	Teixeira, Gustavo Ramos	por
dc.contributor.author	Reis, Monise Tadin	por
dc.contributor.author	Junior, Carlos Roberto Almeida	por
dc.contributor.author	Santos, Karina	por
dc.contributor.author	Melendez, Matias Eliseo	por
dc.contributor.author	Silva, Diego da Cunha Silveira Alves da	por
dc.contributor.author	Bernécule, Priscila Neves	por
dc.contributor.author	Firmino, Higor Vinicius Lourenço	por
dc.contributor.author	Alves, Ana Laura Vieira	por
dc.contributor.author	Guimarães, Denise Peixoto	por
dc.contributor.author	Borduqui, João Vitor	por
dc.contributor.author	Laus, Ana Carolina	por
dc.contributor.author	Mançano, Bruna Minniti	por
dc.contributor.author	Reis, R. M.	por
dc.date.accessioned	2022-12-21T09:57:49Z	-
dc.date.available	2022-12-21T09:57:49Z	-
dc.date.issued	2022-11-16	-
dc.identifier.citation	Teixeira, S.A.; Luzzi, M.d.C.; Martin, A.C.B.M.; Duarte, T.T.; Leal, M.d.O.; Teixeira, G.R.; Reis, M.T.; Junior, C.R.A.; Santos, K.; Melendez, M.E.; Silva, D.d.C.S.A.d.; Bernécule, P.N.; Firmino, H.V.L.; Alves, A.L.V.; Guimarães, D.P.; Borduqui, J.V.; Laus, A.C.; Mançano, B.M.; Reis, R.M. The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models. Vet. Sci. 2022, 9, 636. https://doi.org/10.3390/vetsci9110636	por
dc.identifier.uri	https://hdl.handle.net/1822/81321	-
dc.description.abstract	The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and <i>Apc<sup>Min</sup></i> mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.	por
dc.description.sponsorship	This study was funded by the Public Ministry of Labor Campinas (Research, Prevention and Education of Occupational Cancer) and by Pio XII Foundation, Barretos Cancer Hospital internal funds, Grant Number: 13/2021.	por
dc.language.iso	eng	por
dc.publisher	Multidisciplinary Digital Publishing Institute	por
dc.rights	openAccess	por
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	por
dc.subject	PTCH1-knockout	por
dc.subject	Apc<sup>Min</sup>	por
dc.subject	xenografts	por
dc.subject	PDX	por
dc.subject	genetically engineered mouse models	por
dc.subject	personalized therapy	por
dc.subject	tumor biology	por
dc.subject	Apc(Min)	por
dc.title	The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models	por
dc.type	article	por
dc.peerreviewed	yes	por
dc.relation.publisherversion	https://www.mdpi.com/2306-7381/9/11/636	por
oaire.citationIssue	11	por
oaire.citationVolume	9	por
dc.date.updated	2022-11-24T14:43:42Z	-
dc.identifier.eissn	2306-7381	-
dc.identifier.doi	10.3390/vetsci9110636	por
dc.subject.fos	Ciências Médicas::Outras Ciências Médicas	por
dc.subject.wos	Science & Technology	por
sdum.journal	Veterinary Sciences	por
oaire.version	VoR	por
Aparece nas coleções:	ICVS - Artigos em revistas internacionais / Papers in international journals