Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/81139
Título: | Marine-inspired drugs and biomaterials in the perspective of pancreatic cancer therapies |
Autor(es): | Fernandes, Andreia S. Oliveira, Catarina Reis, R. L. Martins, Albino Silva, Tiago H. |
Palavras-chave: | marine natural products marine biomaterials drug delivery pancreatic cancer anti-tumour biodiscovery |
Data: | 1-Nov-2022 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Marine Drugs |
Citação: | Fernandes, A.S.; Oliveira, C.; Reis, R.L.; Martins, A.; Silva, T.H. Marine-Inspired Drugs and Biomaterials in the Perspective of Pancreatic Cancer Therapies. Mar. Drugs 2022, 20, 689. https://doi.org/10.3390/md20110689 |
Resumo(s): | Despite its low prevalence, pancreatic cancer (PC) is one of the deadliest, typically characterised as silent in early stages and with a dramatically poor prognosis when in its advanced stages, commonly associated with a high degree of metastasis. Many efforts have been made in pursuing innovative therapeutical approaches, from the search for new cytotoxic drugs and other bioactive compounds, to the development of more targeted approaches, including improved drug delivery devices. Marine biotechnology has been contributing to this quest by providing new chemical leads and materials originating from different organisms. In this review, marine biodiscovery for PC is addressed, particularly regarding marine invertebrates (namely sponges, molluscs, and bryozoans), seaweeds, fungi, and bacteria. In addition, the development of biomaterials based on marine-originating compounds, particularly chitosan, fucoidan, and alginate, for the production of advanced cancer therapies, is also discussed. The key role that drug delivery can play in new cancer treatments is highlighted, as therapeutical outcomes need to be improved to give further hope to patients. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/81139 |
DOI: | 10.3390/md20110689 |
e-ISSN: | 1660-3397 |
Versão da editora: | https://www.mdpi.com/1660-3397/20/11/689 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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marinedrugs-20-00689.pdf | 1,23 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons