Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80169
Título: | Boosting the clinical translation of organ-on-a-chip technology |
Autor(es): | Caballero, David Reis, R. L. Kundu, Subhas C |
Palavras-chave: | Clinical Translation disease modelling drug discovery drug screening Microfluidics Organ-on-a-chip personalized medicine |
Data: | Out-2022 |
Editora: | MDPI |
Revista: | Bioengineering |
Citação: | Caballero, D.; Reis, R.L.; Kundu, S.C. Boosting the Clinical Translation of Organ-On-A-Chip Technology. Bioengineering 2022, 9, 549. https://doi.org/10.3390/bioengineering9100549 |
Resumo(s): | Organ-on-a-chip devices have become a viable option for investigating critical physiological events and responses; this technology has matured substantially, and many systems have been reported for disease modeling or drug screening over the last decade. Despite the wide acceptance in the academic community, their adoption by clinical end-users is still a non-accomplished promise. The reasons behind this difficulty can be very diverse but most likely are related to the lack of predictive power, physiological relevance, and reliability necessary for being utilized in the clinical area. In this Perspective, we briefly discuss the main attributes of organ-on-a-chip platforms in academia and how these characteristics impede their easy translation to the clinic. We also discuss how academia, in conjunction with the industry, can contribute to boosting their adoption by proposing novel design concepts, fabrication methods, processes, and manufacturing materials, improving their standardization and versatility, and simplifying their manipulation and reusability. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/80169 |
DOI: | 10.3390/bioengineering9100549 |
e-ISSN: | 2306-5354 |
Versão da editora: | https://www.mdpi.com/2306-5354/9/10/549 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20854-bioengineering-boosting-clinical-translation-ooc-technology.pdf | 632,08 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons