Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/78453

TitleMetronidazole delivery nanosystem able to reduce the pathogenicity of bacteria in colorectal infection
Author(s)Oliveira, Ana
Araújo, Ana
Rodrigues, Luísa C.
Silva, Catarina S.
Reis, R. L.
Neves, N. M.
Leão, Pedro
Martins, Albino
KeywordsAntibacterial
Colorectal
Electrospun fibrous meshes
Metronidazole
Nanoparticles
Issue dateMay-2022
PublisherACS Publications
JournalBiomacromolecules
CitationOliveira A., Araujo A., Rodrigues L.C., Silva C. S., Reis R. L., Neves N. M., Leão P., Martins A. Metronidazole Delivery Nanosystem Able To Reduce the Pathogenicity of Bacteria in Colorectal Infection, Biomacromolecules, Vol. 23, Issue 6, pp. 2415-2427, doi:10.1021/acs.biomac.2c00186, 2022
Abstract(s)Metronidazole (MTZ) is a drug potentially used for the treatment of intestinal infections, namely, the ones caused by colorectal surgery. The traditional routes of administration decrease its local effectiveness and present off-site effects. To circumvent such limitations, herein a drug delivery system (DDS) based on MTZ-loaded nanoparticles (NPs) immobilized at the surface of electrospun fibrous meshes is proposed. MTZ at different concentrations (1, 2, 5, and 10 mg mLâ 1) was loaded into chitosanâ sodium tripolyphosphate NPs. The MTZ loaded into NPs at the highest concentration showed a quick release in the first 12 h, followed by a gradual release. This DDS was not toxic to human colonic cells. When tested against different bacterial strains, a significant reduction of Escherichia coli and Staphylococcus aureus was observed, but no effect was found against Enterococcus faecalis. Therefore, this DDS offers high potential to locally prevent the occurrence of infections after colorectal anastomosis.
TypeArticle
URIhttps://hdl.handle.net/1822/78453
DOI10.1021/acs.biomac.2c00186
ISSN2415-2427
Publisher versionhttps://doi.org/10.1021/acs.biomac.2c00186
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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