Please use this identifier to cite or link to this item:

TitleMetronidazole delivery nanosystem able to reduce the pathogenicity of bacteria in colorectal infection
Author(s)Oliveira, Ana
Araújo, Ana
Rodrigues, Luísa C.
Silva, Catarina S.
Reis, R. L.
Neves, N. M.
Leão, Pedro
Martins, Albino
Electrospun fibrous meshes
Issue dateMay-2022
PublisherACS Publications
CitationOliveira A., Araujo A., Rodrigues L.C., Silva C. S., Reis R. L., Neves N. M., Leão P., Martins A. Metronidazole Delivery Nanosystem Able To Reduce the Pathogenicity of Bacteria in Colorectal Infection, Biomacromolecules, Vol. 23, Issue 6, pp. 2415-2427, doi:10.1021/acs.biomac.2c00186, 2022
Abstract(s)Metronidazole (MTZ) is a drug potentially used for the treatment of intestinal infections, namely, the ones caused by colorectal surgery. The traditional routes of administration decrease its local effectiveness and present off-site effects. To circumvent such limitations, herein a drug delivery system (DDS) based on MTZ-loaded nanoparticles (NPs) immobilized at the surface of electrospun fibrous meshes is proposed. MTZ at different concentrations (1, 2, 5, and 10 mg mLâ 1) was loaded into chitosanâ sodium tripolyphosphate NPs. The MTZ loaded into NPs at the highest concentration showed a quick release in the first 12 h, followed by a gradual release. This DDS was not toxic to human colonic cells. When tested against different bacterial strains, a significant reduction of Escherichia coli and Staphylococcus aureus was observed, but no effect was found against Enterococcus faecalis. Therefore, this DDS offers high potential to locally prevent the occurrence of infections after colorectal anastomosis.
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
  Restricted access
731,42 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID