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https://hdl.handle.net/1822/77877
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Campo DC | Valor | Idioma |
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dc.contributor.author | Caballero, David | por |
dc.contributor.author | Luque-González, Maria Angélica | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Kundu, Subhas C | por |
dc.date.accessioned | 2022-05-24T14:40:08Z | - |
dc.date.issued | 2020-09 | - |
dc.date.submitted | 2020-08 | - |
dc.identifier.citation | Caballero D., Luque-Gonzalez M. A., Reis R. L., Kundu S. C. Microfluidic systems in cancer research, Biomaterials for 3D tumor modeling, Vol. 1, pp. 331-377, 9780128181287, 2020 | por |
dc.identifier.isbn | 9780128181287 | por |
dc.identifier.uri | https://hdl.handle.net/1822/77877 | - |
dc.description.abstract | Cancer remains a major burden in our modern society, being the second leading cause of death worldwide. Many efforts are being made to improve our knowledge about the etiology of the disease, its early diagnosis and treatment. Innovative technologies capable of early detection, diagnosis and monitoring the progression of cancer, as well as the efficiency of the therapies, are needed. Microfluidic devices can provide the needed conditions to boost the investigation in cancer theranostics due to their advanced capabilities and versatility. During the last few years, microfluidics systems have been employed in cancer research for the development of in vitro tumor models to investigate the mechanistic determinants of the disease, for drug screening and discovery applications, or for the fabrication of point-of-care devices for pre-clinical uses. Herein, we review the contribution of microfluidics in cancer research, ranging from fundamental research to clinical and industrial applications. We also discuss about the challenges that microfluidic devices must overcome to be adopted by the market and the society, as well as the future directions in cancer research. | por |
dc.description.sponsorship | The financial support from the Portuguese Foundation for Science and Technology (FCT) under the program CEEC Individual 2017 (CEECIND/00352/2017). D.C. and S.C.K also acknowledge the support from FCT under the scope of the project Modeling Cancer Metastasis into the Human Microcirculation System using a Multi-organ-on-a-Chip Approach (2MATCH) (02/SAICT/2017—no 028070) funded by the Programa Operacional Regional do Norte supported by FEDER. Finally, all the authors acknowledge the financial support from the European Union Framework Programme for Research and Innovation Horizon 2020 on Forefront Research in 3D Disease Cancer Models as in vitro Screening Technologies (FoReCaST) under grant agreement no. 668983 | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00352%2F2017%2FCP1458%2FCT0020/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | Clinical and industrial applications | por |
dc.subject | Microfluidics | por |
dc.subject | Organ-on-chip | por |
dc.subject | Tumor models | por |
dc.subject | Cancer | por |
dc.subject | drug screening | por |
dc.subject | in vitro models | por |
dc.subject | organs-on-a-chip | por |
dc.title | Microfluidic systems in cancer research | por |
dc.type | bookPart | por |
dc.peerreviewed | no | - |
dc.relation.publisherversion | https://www.elsevier.com/books/biomaterials-for-3d-tumor-modeling/kundu/978-0-12-818128-7 | por |
dc.comments | http://3bs.uminho.pt/node/20371 | por |
oaire.citationStartPage | 331 | por |
oaire.citationEndPage | 377 | por |
dc.date.updated | 2022-05-18T10:27:20Z | - |
dc.identifier.doi | 10.1016/B978-0-12-818128-7.00015-0 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.eisbn | 9780128181294 | por |
sdum.bookTitle | Biomaterials for 3D tumor modeling | por |
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