Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/77868
Título: | The tendon microenvironment: engineered in vitro models to study cellular crosstalk |
Autor(es): | Gómez-Florit, Manuel Labrador-Rached, Claudia J. Domingues, Rui Miguel Andrade Gomes, Manuela E. |
Palavras-chave: | 2D models 3D models Regenerative medicine Tendinopathy Tendon Tissue engineering Bioengineering |
Data: | Abr-2022 |
Editora: | Elsevier 1 |
Revista: | Advanced Drug Delivery Reviews |
Citação: | Gómez-Florit M., Labrador-Rached C. J., Domingues R. M. A., Gomes M. E. The tendon microenvironment: Engineered in vitro models to study cellular crosstalk, Advanced Drug Delivery Reviews, Vol. 185, pp. 114299, doi:10.1016/j.addr.2022.114299, 2022 |
Resumo(s): | Tendinopathy is a multi-faceted pathology characterized by alterations in tendon microstructure, cellularity and collagen composition. Challenged by the possibility of regenerating pathological or ruptured tendons, the healing mechanisms of this tissue have been widely researched over the past decades. However, so far, most of the cellular players and processes influencing tendon repair remain unknown, which emphasizes the need for developing relevant in vitro models enabling to study the complex multicellular crosstalk occurring in tendon microenvironments. In this review, we critically discuss the insights on the interaction between tenocytes and the other tendon resident cells that have been devised through different types of existing in vitro models. Building on the generated knowledge, we stress the need for advanced models able to mimic the hierarchical architecture, cellularity and physiological signaling of tendon niche under dynamic culture conditions, along with the recreation of the integrated gradients of its tissue interfaces. In a forward-looking vision of the field, we discuss how the convergence of multiple bioengineering technologies can be leveraged as potential platforms to develop the next generation of relevant in vitro models that can contribute for a deeper fundamental knowledge to develop more effective treatments. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/77868 |
DOI: | 10.1016/j.addr.2022.114299 |
ISSN: | 0169-409X |
e-ISSN: | 1872-8294 |
Versão da editora: | https://doi.org/10.1016/j.addr.2022.114299 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20761-tendon-microenvironment-engineered-vitro-models-study-cellular-crosstalk.pdf | 3,24 MB | Adobe PDF | Ver/Abrir |