Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/7467
Título: | Antifungal activity of a novel chromene dimer |
Autor(es): | Abrunhosa, Luís Costa, M. Areias, F. Venâncio, Armando Proença, M. Fernanda R. P. |
Palavras-chave: | Chromenes Aspergillus spp. Ochratoxin A Antifungal compounds |
Data: | Dez-2007 |
Editora: | Oxford University Press |
Revista: | Journal of Industrial Microbiology and Biotechnology |
Citação: | L Abrunhosa, M Costa, F Areias, A Venâncio, F Proença, Antifungal activity of a novel chromene dimer, Journal of Industrial Microbiology and Biotechnology, Volume 34, Issue 12, 1 December 2007, Pages 787–792, https://doi.org/10.1007/s10295-007-0255-z |
Resumo(s): | The activity on Aspergillus spp. growth and on ochratoxin A production of two novel chromene dimers (3) was evaluated. The results of the bioassays indicate that the chromene dimer 3a inhibited mycelia growth by approximately 50% (EC50) at 140.1 μmol L−1 for A. niger, 384.2 μmol L−1 for A. carbonarius, 69.1 μmol L−1 for A. alliaceus and 559.1 μmol L−1 for A. ochraceus. When applied at concentrations of 2 mmol L−1, 3a totally inhibited the growth of all Aspergillus spp. tested. Furthermore, ochratoxin A production by A. alliaceus was reduced by about 94% with a 200 μmol L−1 solution of this compound. A moderate inhibitory effect was observed for the analogous structure 3b on ochratoxin A production but not in mycelia growth. No inhibition was registered for compounds 2a and 2b, used as synthetic precursors of the dimeric species 3. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/7467 |
DOI: | 10.1007/s10295-007-0255-z |
ISSN: | 1367-5435 |
e-ISSN: | 1476-5535 |
Versão da editora: | https://academic.oup.com/jimb/article/34/12/787/5993107 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Abrunhosa_etal_2007_JIMB.pdf | 488,26 kB | Adobe PDF | Ver/Abrir |