Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/73530

TitlePhysicochemical features assessment of acemannan-based ternary blended films for biomedical purposes
Author(s)Rodrigues, Luísa Cidália Guimarães
Fernandes, Emanuel Mouta
Ribeiro, Ana R.
Ribeiro, Adriana P.
Silva, Simone S.
Reis, R. L.
KeywordsAcemannan
ALGINATE
Aloe vera
bioactive agents
BIOMEDICAL APPLICATIONS
Blend Films
Chitosan
Blend
Films
Issue dateApr-2021
PublisherElsevier
JournalCarbohydrate Polymers
CitationRodrigues L.C., Fernandes E. M., Ribeiro A. R., Ribeiro A. P., Silva S. S., Reis R. L. Physicochemical features assessment of acemannan-based ternary blended films for biomedical purposes, Carbohydrate Polymers, Vol. 257, pp. 117601, doi:10.1016/j.carbpol.2020.117601, 2021
Abstract(s)The exploitation of natural origin macromolecules, as complex physical mixtures or drugs, increases in biomedical or tissue engineering (TE) solutions. Aloe Vera is a highly explored medicinal plant, from which the main polysaccharide is acemannan (ACE). The ACE combination with chitosan and alginate results in interactions that lead to mixed junction zones formation, predicting membrane functionality improvement. This work proposes the development and characterization of ACE-based blended films as a promising strategy to design a nature-derived bioactive platform. The results confirmed that stable complex polyelectrolyte structures were formed through different intermolecular interactions. The films present good dimensional stability, flexibility, an adequate swelling ability with mostly radial water uptake, and a sustainable ACE release to the medium. Positive biological performance of the ACE-based blended films with L929 cells also suggested that they can be applied in TE solutions, with the potential to act as bioactive topical platforms.
TypeArticle
URIhttps://hdl.handle.net/1822/73530
DOI10.1016/j.carbpol.2020.117601
ISSN0144-8617
Publisher versionhttps://www.sciencedirect.com/science/article/abs/pii/S0144861720317744
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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