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https://hdl.handle.net/1822/67371
Título: | Association between EGF +61 genetic polymorphisms and non-small cell lung cancer increased risk in a Portuguese population: a case-control study |
Autor(es): | Mello, Ramon Andrade de Ferreira, Mónica Costa, Sandra Costa, Bruno Marques Pires, Filipa Soares Neves, Inês Almeida, Maria Inês Cunha, João Oliveira, Pedro Hespanhol, Venceslau Reis, R. M. |
Palavras-chave: | Adult Aged Aged, 80 and over Alleles Carcinoma, Non-Small-Cell Lung Case-Control Studies Epidermal Growth Factor Female Genetic Predisposition to Disease Genotype Humans Lung Neoplasms Male Middle Aged Neoplasm Staging Portugal Reproducibility of Results Risk Polymorphism, Single Nucleotide Non-small cell lung cancer Genetic polymorphism Risk assessment |
Data: | Out-2012 |
Editora: | Springer |
Revista: | Tumor Biology |
Citação: | de Mello, R.A., Ferreira, M., Costa, S. et al. Association between EGF +61 genetic polymorphisms and non-small cell lung cancer increased risk in a Portuguese population: a case–control study. Tumor Biol. 33, 1341–1348 (2012). https://doi.org/10.1007/s13277-012-0382-7 |
Resumo(s): | Epidermal growth factor (EGF) and its receptor play critical roles in non-small cell lung cancer (NSCLC) carcinogenesis. A functional polymorphism in the EGF gene has been linked to increased cancer susceptibility. This study aimed to evaluate the role of the EGF +61A/G polymorphism as risk factors in NSCLC patients. For the present case-control study, we analyzed 112 NSCLC and 126 cancer-free controls from Portugal. Following DNA isolation from peripheral blood, EGF +61A/G polymorphism was assessed by polymerase chain reaction-restriction fragment length polymorphism. Univariate and multivariate logistic regression analyses were used to calculate odds ratio (OR) and 95 % confidence intervals (95 % CI). False-positive report probability was also assessed. The EGF +61 genotypes frequencies in NSCLC were AA (23.2 %), AG (51.8 %), and GG (25 %) and in controls, AA (40.5 %), AG (41.3 %), and GG (18.3 %). When compared to the reference genotype (EGF +61A/A), we found a statistically significant association between EGF +61 A/G (OR = 2.142, 95 % CI 1.170-3.924) and EGF +61G/G (OR = 2.398, 95 % CI 1.157-4.968) genotypes and susceptibility to development of NSCLC. Furthermore, stratification by sex revealed a trend to increased risk of males carrying +61A/G genotype for developing NSCLC (OR = 2.044, 95 % CI 0.998-4.188) when compared to A/A genotype. Our data suggest an increased risk to develop NSCLC in Portuguese population carrying the EGF +61A/G and +61G/G genotypes. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67371 |
DOI: | 10.1007/s13277-012-0382-7 |
ISSN: | 1010-4283 |
e-ISSN: | 1423-0380 |
Versão da editora: | https://link.springer.com/article/10.1007/s13277-012-0382-7 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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demello2012.pdf Acesso restrito! | 179,77 kB | Adobe PDF | Ver/Abrir |