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https://hdl.handle.net/1822/67371
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Campo DC | Valor | Idioma |
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dc.contributor.author | Mello, Ramon Andrade de | por |
dc.contributor.author | Ferreira, Mónica | por |
dc.contributor.author | Costa, Sandra | por |
dc.contributor.author | Costa, Bruno Marques | por |
dc.contributor.author | Pires, Filipa Soares | por |
dc.contributor.author | Neves, Inês | por |
dc.contributor.author | Almeida, Maria Inês | por |
dc.contributor.author | Cunha, João | por |
dc.contributor.author | Oliveira, Pedro | por |
dc.contributor.author | Hespanhol, Venceslau | por |
dc.contributor.author | Reis, R. M. | por |
dc.date.accessioned | 2020-10-08T09:53:14Z | - |
dc.date.issued | 2012-10 | - |
dc.identifier.citation | de Mello, R.A., Ferreira, M., Costa, S. et al. Association between EGF +61 genetic polymorphisms and non-small cell lung cancer increased risk in a Portuguese population: a case–control study. Tumor Biol. 33, 1341–1348 (2012). https://doi.org/10.1007/s13277-012-0382-7 | por |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://hdl.handle.net/1822/67371 | - |
dc.description.abstract | Epidermal growth factor (EGF) and its receptor play critical roles in non-small cell lung cancer (NSCLC) carcinogenesis. A functional polymorphism in the EGF gene has been linked to increased cancer susceptibility. This study aimed to evaluate the role of the EGF +61A/G polymorphism as risk factors in NSCLC patients. For the present case-control study, we analyzed 112 NSCLC and 126 cancer-free controls from Portugal. Following DNA isolation from peripheral blood, EGF +61A/G polymorphism was assessed by polymerase chain reaction-restriction fragment length polymorphism. Univariate and multivariate logistic regression analyses were used to calculate odds ratio (OR) and 95 % confidence intervals (95 % CI). False-positive report probability was also assessed. The EGF +61 genotypes frequencies in NSCLC were AA (23.2 %), AG (51.8 %), and GG (25 %) and in controls, AA (40.5 %), AG (41.3 %), and GG (18.3 %). When compared to the reference genotype (EGF +61A/A), we found a statistically significant association between EGF +61 A/G (OR = 2.142, 95 % CI 1.170-3.924) and EGF +61G/G (OR = 2.398, 95 % CI 1.157-4.968) genotypes and susceptibility to development of NSCLC. Furthermore, stratification by sex revealed a trend to increased risk of males carrying +61A/G genotype for developing NSCLC (OR = 2.044, 95 % CI 0.998-4.188) when compared to A/A genotype. Our data suggest an increased risk to develop NSCLC in Portuguese population carrying the EGF +61A/G and +61G/G genotypes. | por |
dc.description.sponsorship | The authors acknowledge all colleagues from SãoJoão Hospital (HSJ), Porto, Portugal (specially Professor Agostinho Marques, Dr. Idalina Araújo, Dr. Alice Barbosa, Dr. António Morais, nd Dr. Adriana Magalhães) and São Marcos Hospital, Braga, Portugal who directly or indirectly contributed for this work; all Day Hospital Nurses of HSJ (specially Nurse Fátima Figueiredo); Professor Henrique Queiroga, University of Porto, Porto, Portugal, for his critical contribu-tion; and Mr. Fernando Ferreira, HSJ Day Hospital Service, for this logistic contribution. We would like also to thank the Immuno hemotherapy Department of Hospital São Marcos, Braga, Portugal and Clínica Laboratorial Dr. Edgar Botelho Moniz, Santo Tirso, Portugal for their helpful assistance in the management of controls. This work was supported by ICVS internal research funds to Dr. Rui Manuel Reis. | por |
dc.language.iso | eng | por |
dc.publisher | Springer | por |
dc.rights | restrictedAccess | por |
dc.subject | Adult | por |
dc.subject | Aged | por |
dc.subject | Aged, 80 and over | por |
dc.subject | Alleles | por |
dc.subject | Carcinoma, Non-Small-Cell Lung | por |
dc.subject | Case-Control Studies | por |
dc.subject | Epidermal Growth Factor | por |
dc.subject | Female | por |
dc.subject | Genetic Predisposition to Disease | por |
dc.subject | Genotype | por |
dc.subject | Humans | por |
dc.subject | Lung Neoplasms | por |
dc.subject | Male | por |
dc.subject | Middle Aged | por |
dc.subject | Neoplasm Staging | por |
dc.subject | Portugal | por |
dc.subject | Reproducibility of Results | por |
dc.subject | Risk | por |
dc.subject | Polymorphism, Single Nucleotide | por |
dc.subject | Non-small cell lung cancer | por |
dc.subject | Genetic polymorphism | por |
dc.subject | Risk assessment | por |
dc.title | Association between EGF +61 genetic polymorphisms and non-small cell lung cancer increased risk in a Portuguese population: a case-control study | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s13277-012-0382-7 | por |
oaire.citationStartPage | 1341 | por |
oaire.citationEndPage | 1348 | por |
oaire.citationIssue | 5 | por |
oaire.citationVolume | 33 | por |
dc.identifier.eissn | 1423-0380 | - |
dc.identifier.doi | 10.1007/s13277-012-0382-7 | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 22457050 | por |
dc.subject.fos | Ciências Médicas::Ciências da Saúde | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Tumor Biology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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demello2012.pdf Acesso restrito! | 179,77 kB | Adobe PDF | Ver/Abrir |