Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67337
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Amorim, Sara | por |
dc.contributor.author | Costa, Diana Soares da | por |
dc.contributor.author | Pashkuleva, Iva | por |
dc.contributor.author | Reis, Celso A. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Pires, R. A. | por |
dc.date.accessioned | 2020-10-07T15:02:21Z | - |
dc.date.available | 2020-10-07T15:02:21Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2020 | - |
dc.identifier.citation | Amorim S., Soares da Costa D., Pashkuleva I., Reis C. A., Reis R. L., Pires R. A. Hyaluronic Acid of Low Molecular Weight Triggers the Invasive “Hummingbird” Phenotype on Gastric Cancer Cells, Advanced Biosystems, pp. 2000122, doi:10.1002/adbi.202000122, 2020 | por |
dc.identifier.issn | 2366-7478 | por |
dc.identifier.uri | https://hdl.handle.net/1822/67337 | - |
dc.description.abstract | The overproduction and deposition of hyaluronic acid (HA) of different sizes in the tumor microenvironment is associated with cancer metastasis. Here, the development of layerâ byâ layer (LbL) constructs containing HA of different molecular weights (i.e., 5.6, 618, and 1450Â kDa) that mimic the HAâ rich cancer extracellular matrix is described to study the effect of the HA's size on the behavior of gastric cancer cells (AGS). The results demonstrate that LbL constructs with short HA, i.e., 5.6Â kDa, activate the cytoskeleton rearrangement leading to the â hummingbirdâ morphology, promote high cellular motility, and activate signaling pathways with increased expression of pâ ERK1/2 and pâ AKT. In addition, it is demonstrated that this malignant transformation involves an active participation of the HA coreceptor RHAMM in AGS cells. | por |
dc.description.sponsorship | The authors acknowledge the financial support from the European Commission’s H2020 Programme, under grant agreements H2020-WIDESPREAD-2014-668983-FORECAST and H2020-MSCA-RISE-2019-872648-MEPHOS. S.A. acknowledge the Portuguese Foundation for Science and Technology (FCT) for the PhD grant (SFRH/BD/112075/2015). The authors also thank Ramon Novoa-Caballal for performing the GPC experiments and data analysis. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.rights | openAccess | por |
dc.subject | Gastric cancer | por |
dc.subject | Hummingbird phenotype | por |
dc.subject | Hyaluronic acid | por |
dc.subject | cancer invasiveness | por |
dc.subject | hummingbird | por |
dc.subject | molecular weight | por |
dc.title | Hyaluronic acid of low molecular weight triggers the invasive “hummingbird” phenotype on gastric cancer cells | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/adbi.202000122 | por |
dc.comments | http://3bs.uminho.pt/node/20387 | por |
oaire.citationIssue | 11 | por |
oaire.citationVolume | 4 | por |
dc.date.updated | 2020-10-06T09:03:39Z | - |
dc.identifier.doi | 10.1002/adbi.202000122 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Advanced Biosystems | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20387-Amorim_2020.pdf | 1,35 MB | Adobe PDF | Ver/Abrir |