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https://hdl.handle.net/1822/67267
Título: | Definition of the anti-inflammatory oligosaccharides derived from the galactosaminogalactan (GAG) from Aspergillus fumigatus |
Autor(es): | Gressler, Markus Heddergott, Christoph N'Go, Inés C. Renga, Giorgia Oikonomou, Vasilis Moretti, Silvia Coddeville, Bernadette Gaifem, Joana Silvestre, Ricardo Jorge Leal Romani, Luigina Latgé, Jean-Paul Fontaine, Thierry |
Palavras-chave: | Animals Anti-Inflammatory Agents Aspergillus fumigatus Colitis Dextran Sulfate Humans Interleukin 1 Receptor Antagonist Protein Leukocytes, Mononuclear Mice Oligosaccharides Polysaccharides Polysaccharides, Bacterial Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Galactosaminogalactan IL-Ra Anti-inflammatory response Glycodrug |
Data: | Nov-2019 |
Editora: | Frontiers Media |
Revista: | Frontiers in Cellular and Infection Microbiology |
Citação: | Fontaine, T., Gressler, M., Heddergott, C., Renga, G., et. al. (2019). Definition of the anti-inflammatory oligosaccharides derived from the galactosaminogalactan (GAG) from Aspergillus fumigatus. Frontiers in cellular and infection microbiology, 9, 365 |
Resumo(s): | Galactosaminogalactan (GAG) is an insoluble aminosugar polymer produced by Aspergillus fumigatus and has anti-inflammatory properties. Here, the minimum glycosidic sequences required for the induction of IL-1Ra by peripheral blood mononuclear cells (PBMCs) was investigated. Using chemical degradation of native GAG to isolate soluble oligomers, we have found that the de-N-acetylation of galactosamine residues and the size of oligomer are critical for the in vitro immune response. A minimal oligomer size of 20 galactosamine residues is required for the anti-inflammatory response but the presence of galactose residues is not necessary. In a Dextran sulfate induced colitis mouse model, a fraction of de-N-acetylated oligomers of 13 < dp < 20 rescue inflammatory damage like the native GAG polymer in an IL-1Ra dependent pathway. Our results demonstrate the therapeutic suitability of water-soluble GAG oligosaccharides in IL-1 mediated hyper-inflammatory diseases and suggest that α-1,4-galactosamine oligomers chemically synthesized could represent new anti-inflammatory glycodrugs. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67267 |
DOI: | 10.3389/fcimb.2019.00365 |
ISSN: | 2235-2988 |
e-ISSN: | 2235-2988 |
Versão da editora: | https://www.frontiersin.org/articles/10.3389/fcimb.2019.00365/full |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Gressler-2019-Definition-of-the-anti-inflammatory.pdf | 1,13 MB | Adobe PDF | Ver/Abrir |