Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67267
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Gressler, Markus | por |
dc.contributor.author | Heddergott, Christoph | por |
dc.contributor.author | N'Go, Inés C. | por |
dc.contributor.author | Renga, Giorgia | por |
dc.contributor.author | Oikonomou, Vasilis | por |
dc.contributor.author | Moretti, Silvia | por |
dc.contributor.author | Coddeville, Bernadette | por |
dc.contributor.author | Gaifem, Joana | por |
dc.contributor.author | Silvestre, Ricardo Jorge Leal | por |
dc.contributor.author | Romani, Luigina | por |
dc.contributor.author | Latgé, Jean-Paul | por |
dc.contributor.author | Fontaine, Thierry | por |
dc.date.accessioned | 2020-10-02T16:32:56Z | - |
dc.date.available | 2020-10-02T16:32:56Z | - |
dc.date.issued | 2019-11 | - |
dc.identifier.citation | Fontaine, T., Gressler, M., Heddergott, C., Renga, G., et. al. (2019). Definition of the anti-inflammatory oligosaccharides derived from the galactosaminogalactan (GAG) from Aspergillus fumigatus. Frontiers in cellular and infection microbiology, 9, 365 | por |
dc.identifier.issn | 2235-2988 | por |
dc.identifier.uri | https://hdl.handle.net/1822/67267 | - |
dc.description.abstract | Galactosaminogalactan (GAG) is an insoluble aminosugar polymer produced by Aspergillus fumigatus and has anti-inflammatory properties. Here, the minimum glycosidic sequences required for the induction of IL-1Ra by peripheral blood mononuclear cells (PBMCs) was investigated. Using chemical degradation of native GAG to isolate soluble oligomers, we have found that the de-N-acetylation of galactosamine residues and the size of oligomer are critical for the in vitro immune response. A minimal oligomer size of 20 galactosamine residues is required for the anti-inflammatory response but the presence of galactose residues is not necessary. In a Dextran sulfate induced colitis mouse model, a fraction of de-N-acetylated oligomers of 13 < dp < 20 rescue inflammatory damage like the native GAG polymer in an IL-1Ra dependent pathway. Our results demonstrate the therapeutic suitability of water-soluble GAG oligosaccharides in IL-1 mediated hyper-inflammatory diseases and suggest that α-1,4-galactosamine oligomers chemically synthesized could represent new anti-inflammatory glycodrugs. | por |
dc.description.sponsorship | Aviesan project Aspergillus, the French Government's Investissement d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases (Grant No ANR-10-LABX-62-IBEID), la Fondation pour la Recherche Médicale (DEQ20150331722 LATGE Equipe FRM 2015). RS thanks Fundação para a Ciência e Tecnologia (FCT) contract IF/00021/2014 | por |
dc.language.iso | eng | por |
dc.publisher | Frontiers Media | por |
dc.rights | openAccess | por |
dc.subject | Animals | por |
dc.subject | Anti-Inflammatory Agents | por |
dc.subject | Aspergillus fumigatus | por |
dc.subject | Colitis | por |
dc.subject | Dextran Sulfate | por |
dc.subject | Humans | por |
dc.subject | Interleukin 1 Receptor Antagonist Protein | por |
dc.subject | Leukocytes, Mononuclear | por |
dc.subject | Mice | por |
dc.subject | Oligosaccharides | por |
dc.subject | Polysaccharides | por |
dc.subject | Polysaccharides, Bacterial | por |
dc.subject | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | por |
dc.subject | Galactosaminogalactan | por |
dc.subject | IL-Ra | por |
dc.subject | Anti-inflammatory response | por |
dc.subject | Glycodrug | por |
dc.title | Definition of the anti-inflammatory oligosaccharides derived from the galactosaminogalactan (GAG) from Aspergillus fumigatus | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fcimb.2019.00365/full | por |
oaire.citationVolume | 9 | por |
dc.identifier.eissn | 2235-2988 | - |
dc.identifier.doi | 10.3389/fcimb.2019.00365 | por |
dc.identifier.pmid | 31781511 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Frontiers in Cellular and Infection Microbiology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Gressler-2019-Definition-of-the-anti-inflammatory.pdf | 1,13 MB | Adobe PDF | Ver/Abrir |