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https://hdl.handle.net/1822/66922
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Campo DC | Valor | Idioma |
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dc.contributor.author | Vinhas, Adriana | por |
dc.contributor.author | Rodrigues, Márcia T. | por |
dc.contributor.author | Gonçalves, A I | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Gomes, Manuela E. | por |
dc.date.accessioned | 2020-09-11T13:37:36Z | - |
dc.date.available | 2020-09-11T13:37:36Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Vinhas A., Rodrigues M. T., Gonçalves A. I., Reis R. L., Gomes M. E. Pulsed Electromagnetic Field Modulates Tendon Cells Response in IL‐1β‐Conditioned Environment, Journal Of Orthopaedic Research, Vol. 38, Issue 1, pp. 160-172, doi:10.1002/jor.24538, 2020. | por |
dc.identifier.issn | 0736-0266 | por |
dc.identifier.uri | https://hdl.handle.net/1822/66922 | - |
dc.description.abstract | Strategies aiming at controlling and modulating inflammatory cues may offer therapeutic solutions for improving tendon regeneration. This study aims to investigate the modulatory effect of pulsed electromagnetic field (PEMF) on the inflammatory profile of human tendonâ derived cells (hTDCs) after supplementation with interleukinâ 1β (ILâ 1β). ILâ 1β was used to artificially induce in-flammatory cues associated with injured tendon environments. The PEMF effect was investigated varying the frequency (5 or 17 Hz), intensity (1.5, 4, or 5 mT), and dutyâ cycle (10% or 50%) parameters to which ILâ 1βâ treated hTDCs were exposed to. A PEMF actuation with 4 mT, 5 Hz and a 50% duty cycle decreased the production of ILâ 6 and tumor necrosis factorâ α (TNFâ α), as well as the expression of TNFα, ILâ 6, ILâ 8, COXâ 2, MMPâ 1, MMPâ 2, and MMPâ 3, while ILâ 4, ILâ 10, and TIMPâ 1 expression increased. These results suggest that PEMF stimulation can modulate hTDCs response in an inflammatory environment holding therapeutic potential for tendon regenerative strategies. | por |
dc.description.sponsorship | The authors thank Hospital da Prelada (Porto, Portugal) for providing tendon tissue and acknowledge the financial support from Fundação para a Ciência e Tecnologia (FCT) for the doctoral grant PD/BD/128089/2016 and for MagTT project PTDC/CTM‐CTM/29930/2017 (POCI‐01‐0145‐FEDER‐29930), the project NORTE‐01‐0145‐FEDER‐000021 supported by Norte Portugal Regional Operational Programme (NORTE 2020), HORIZON 2020 under the TEAMING GRANT agreement No 739572—The Discoveries CTR and MagTendon No. 772817. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley | por |
dc.rights | openAccess | por |
dc.subject | Cytokines | por |
dc.subject | Human tendon‐derived cells | por |
dc.subject | IL‐1β | por |
dc.subject | Inflammation | por |
dc.subject | Pulsed electromagnetic field | por |
dc.subject | IL-1 beta | por |
dc.title | Pulsed electromagnetic field modulates tendon cells response in il‐1β‐conditioned environment | por |
dc.type | article | - |
dc.peerreviewed | no | por |
dc.relation.publisherversion | https://doi.org/10.1002/jor.24538 | por |
dc.comments | http://3bs.uminho.pt/node/20373 | por |
oaire.citationStartPage | 160 | por |
oaire.citationEndPage | 172 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 38 | por |
dc.date.updated | 2020-09-04T07:50:36Z | - |
dc.identifier.eissn | 1554-527X | por |
dc.identifier.doi | 10.1002/jor.24538 | por |
dc.identifier.pmid | 31769535 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Orthopaedic Research | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20373-Pulsed Electromagnetic Field Modulates Tendon Cells Response in IL‐1β‐Conditioned Environment.pdf | 8,7 MB | Adobe PDF | Ver/Abrir |