Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/66379
Título: | Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine |
Autor(es): | Casanova, Marta Alexandra Rodrigues Reis, R. L. Martins, Albino Neves, N. M. |
Palavras-chave: | Bioactive molecules Biomaterials Substrate Growth factors Surface functionalization Surface Immobilization Tissue engineering and regenerative medicine |
Data: | Mai-2020 |
Editora: | Royal Society of Chemistry |
Revista: | Materials Horizons |
Citação: | Casanova M. R., Reis R. L., Martins A., Neves N. M. Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine, Materials Horizons, pp. 1-18, doi:10.1039/D0MH00542H, 2020 |
Resumo(s): | Surface biofunctionalization has emerged in the past decade as a rising tool in Tissue Engineering and Regenerative Medicine (TERM) approaches. The development of biomaterial substrates with regenerative properties is challenging, mainly due to the requirement of obtaining a surface that promotes cell attachment, proliferation and differentiation. Biomolecules, namely extracellular matrix proteins and growth factors, play a key role in the wound healing cascade, mediating a wide range of cellular activities. Therefore, the immobilization of such biomolecules at the surface of biomaterials has a remarkable interest for TERM strategies. Numerous variants can be used to biofunctionalize the surface of biomaterials, being classified as non-covalent and covalent immobilization strategies. Importantly, the maintenance of stable/available bioactive factors needs also to be considered. In this review, a wide range of bioactive molecules and different biofunctionalization strategies will be discussed, as well as the most relevant results achieved in the novel and most promising strategies. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/66379 |
DOI: | 10.1039/D0MH00542H |
ISSN: | 2051-6347 |
e-ISSN: | 2051-6355 |
Versão da editora: | http://dx.doi.org/10.1039/D0MH00542H |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20326-10.1039@D0MH00542H(1).pdf Acesso restrito! | 1,42 MB | Adobe PDF | Ver/Abrir |