Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/62316

TitleTET enzymes in neurophysiology and brain function
Author(s)Antunes, Cláudia
Sousa, Nuno
Pinto, Luísa
Marques, C. Joana
KeywordsNeuronal plasticity
Behavior
Epigenetics
TET enzymes
5hmC
Issue date2019
PublisherElsevier
JournalNeuroscience and Biobehavioral Reviews
CitationAntunes, C., Sousa, N., Pinto, L., & Marques, C. J. (2019). TET enzymes in neurophysiology and brain function. Neuroscience & Biobehavioral Reviews.
Abstract(s)The dynamic nature of epigenetic DNA modifications is crucial for regulating gene expression in an experience-dependent manner and, thus, a potential mediator of neuronal plasticity and behavior. The discovery of the involvement of 5-hydroxymethylcytosine (5hmC) and Ten Eleven Translocation (TET) family of enzymes in the demethylation pathway uncovered a potential link between neuronal TET protein function and cognitive processes. In this review, we provide an overview on how profile of 5hmC and TET enzymes are powerful mechanisms to explain neuronal plasticity and long-term behaviors, such as cognition. More specifically, we discuss how the current knowledge integrates the function of each TET enzyme in neurophysiology and brain function.
TypeArticle
URIhttps://hdl.handle.net/1822/62316
DOI10.1016/j.neubiorev.2019.05.006
ISSN0149-7634
e-ISSN1873-7528
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S014976341830856X
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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