Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62316
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Antunes, Cláudia | por |
dc.contributor.author | Sousa, Nuno | por |
dc.contributor.author | Pinto, Luísa | por |
dc.contributor.author | Marques, C. Joana | por |
dc.date.accessioned | 2019-11-21T15:45:24Z | - |
dc.date.available | 2024-01-01T07:00:32Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Antunes, C., Sousa, N., Pinto, L., & Marques, C. J. (2019). TET enzymes in neurophysiology and brain function. Neuroscience & Biobehavioral Reviews. | por |
dc.identifier.issn | 0149-7634 | - |
dc.identifier.uri | https://hdl.handle.net/1822/62316 | - |
dc.description.abstract | The dynamic nature of epigenetic DNA modifications is crucial for regulating gene expression in an experience-dependent manner and, thus, a potential mediator of neuronal plasticity and behavior. The discovery of the involvement of 5-hydroxymethylcytosine (5hmC) and Ten Eleven Translocation (TET) family of enzymes in the demethylation pathway uncovered a potential link between neuronal TET protein function and cognitive processes. In this review, we provide an overview on how profile of 5hmC and TET enzymes are powerful mechanisms to explain neuronal plasticity and long-term behaviors, such as cognition. More specifically, we discuss how the current knowledge integrates the function of each TET enzyme in neurophysiology and brain function. | por |
dc.description.sponsorship | Portuguese Foundation for Science and Technology (FCT) fellowships (PD/BD/106049/2015 to C.A., IF/01079/2014 to L.P. and IF/00047/2012 and CEECIND/00371/2017 to C.J.M); FCT project grant (PTDC/BIA-BCM/121276/2010) to C.J.M; EpiGeneSys Small Collaborative project to L.P.; BIAL Foundation Grant427/14 to L.P.; Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER; NORTE-01-0145-FEDER-000013); FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and National Funds, through the FCT (POCI-01-0145-FEDER-007038) | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/FARH/PD%2FBD%2F106049%2F2015/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01079%2F2014%2FCP1212%2FCT0017/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00047%2F2012%2FCP0177%2FCT0001/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00371%2F2017%2FCP1413%2FCT0002/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FBIA-BCM%2F121276%2F2010/PT | - |
dc.rights | openAccess | por |
dc.subject | Neuronal plasticity | por |
dc.subject | Behavior | por |
dc.subject | Epigenetics | por |
dc.subject | TET enzymes | por |
dc.subject | 5hmC | por |
dc.title | TET enzymes in neurophysiology and brain function | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S014976341830856X | por |
dc.comments | 48 meses | por |
oaire.citationStartPage | 337 | por |
oaire.citationEndPage | 344 | por |
oaire.citationVolume | 102 | por |
dc.identifier.eissn | 1873-7528 | - |
dc.identifier.doi | 10.1016/j.neubiorev.2019.05.006 | por |
dc.identifier.pmid | 31078565 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Neuroscience and Biobehavioral Reviews | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Tet enzymes in neurophysiology and brain function.pdf | 414,24 kB | Adobe PDF | Ver/Abrir |