Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/60057
Título: | Magnetic dehydrodipeptide-based self-assembled hydrogels for theragnostic applications |
Autor(es): | Carvalho, André Gallo, Juan Pereira, David M. Valentão, Patrícia Andrade, Paula B. Hilliou, L. Ferreira, Paula M. T. Bañobre-López, Manuel Martins, J. A. |
Palavras-chave: | naproxen N-capped dehydrodipeptides self-assembled hydrogels SPION magnetic hydrogels MRI magnetic hyperthermia drug-delivery |
Data: | 3-Abr-2019 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Nanomaterials |
Resumo(s): | Self-assembled peptide hydrogels have emerged in recent years as the new paradigm in biomaterials research. We have contributed to this field the development of hydrogels based on dehydrodipeptides <i>N</i>-capped with naproxen. The dehydrodipeptide hydrogels can be loaded with drugs, thus being potential nanocarriers for drug delivery. In this work novel dehydrodipeptides containing tyrosine and aspartic acid amino acid residues <i>N</i>-capped with naproxen and <i>C</i>-terminal dehydrophenylalanine were prepared and characterized. Superparamagnetic iron oxide nanoparticles (SPIONs) were incorporated into the dehydrodipeptide-based hydrogels and their effect on the self-assembly, structure and rheological and magnetic properties of the hydrogels was studied. Magnetic hydrogels, with incorporated SPIONs, displayed concentration-dependent <i>T</i><sub>2</sub>-MRI contrast enhancement. Moreover, upon magnetic excitation (alternating magnetic field –AMF–) the SPIONs were able to generate a significant amount of heat. Hence, magnetic hyperthermia can be used as a remote trigger for release of drug cargos and SPIONs incorporated into the self-assembled dehydrodipeptide hydrogels. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/60057 |
DOI: | 10.3390/nano9040541 |
ISSN: | 2079-4991 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) IPC - Artigos em revistas científicas internacionais com arbitragem |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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nanomaterials-09-00541.pdf | 2,08 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons