Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/60057
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Campo DC | Valor | Idioma |
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dc.contributor.author | Carvalho, André | por |
dc.contributor.author | Gallo, Juan | por |
dc.contributor.author | Pereira, David M. | por |
dc.contributor.author | Valentão, Patrícia | por |
dc.contributor.author | Andrade, Paula B. | por |
dc.contributor.author | Hilliou, L. | por |
dc.contributor.author | Ferreira, Paula M. T. | por |
dc.contributor.author | Bañobre-López, Manuel | por |
dc.contributor.author | Martins, J. A. | por |
dc.date.accessioned | 2019-04-15T21:16:02Z | - |
dc.date.available | 2019-04-15T21:16:02Z | - |
dc.date.issued | 2019-04-03 | - |
dc.identifier.issn | 2079-4991 | por |
dc.identifier.uri | https://hdl.handle.net/1822/60057 | - |
dc.description.abstract | Self-assembled peptide hydrogels have emerged in recent years as the new paradigm in biomaterials research. We have contributed to this field the development of hydrogels based on dehydrodipeptides <i>N</i>-capped with naproxen. The dehydrodipeptide hydrogels can be loaded with drugs, thus being potential nanocarriers for drug delivery. In this work novel dehydrodipeptides containing tyrosine and aspartic acid amino acid residues <i>N</i>-capped with naproxen and <i>C</i>-terminal dehydrophenylalanine were prepared and characterized. Superparamagnetic iron oxide nanoparticles (SPIONs) were incorporated into the dehydrodipeptide-based hydrogels and their effect on the self-assembly, structure and rheological and magnetic properties of the hydrogels was studied. Magnetic hydrogels, with incorporated SPIONs, displayed concentration-dependent <i>T</i><sub>2</sub>-MRI contrast enhancement. Moreover, upon magnetic excitation (alternating magnetic field –AMF–) the SPIONs were able to generate a significant amount of heat. Hence, magnetic hyperthermia can be used as a remote trigger for release of drug cargos and SPIONs incorporated into the self-assembled dehydrodipeptide hydrogels. | por |
dc.description.sponsorship | This work is funded by National Funds through FCT - Portuguese Foundation for Science and Technology under the Project PTDC/QUI-QOR/29015/2017 and CQ/UM UID/QUI/00686/2013 and UID/QUI/0686/2016. The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project No 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute | por |
dc.relation | PTDC/QUI-QOR/29015/2017 | por |
dc.relation | UID/QUI/00686/2013 | por |
dc.relation | UID/QUI/0686/2016 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | naproxen N-capped dehydrodipeptides | por |
dc.subject | self-assembled hydrogels | por |
dc.subject | SPION | por |
dc.subject | magnetic hydrogels | por |
dc.subject | MRI | por |
dc.subject | magnetic hyperthermia | por |
dc.subject | drug-delivery | por |
dc.title | Magnetic dehydrodipeptide-based self-assembled hydrogels for theragnostic applications | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 9 | por |
dc.date.updated | 2019-04-11T11:09:19Z | - |
dc.identifier.doi | 10.3390/nano9040541 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Nanomaterials | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) IPC - Artigos em revistas científicas internacionais com arbitragem |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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nanomaterials-09-00541.pdf | 2,08 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons